ID L9JF38_TUPCH Unreviewed; 2353 AA.
AC L9JF38;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=ATP-binding cassette sub-family A member 12 {ECO:0000313|EMBL:ELW49201.1};
GN ORFNames=TREES_T100001933 {ECO:0000313|EMBL:ELW49201.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW49201.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB321002; ELW49201.1; -; Genomic_DNA.
DR STRING; 246437.L9JF38; -.
DR eggNOG; KOG0059; Eukaryota.
DR InParanoid; L9JF38; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF29; GLUCOSYLCERAMIDE TRANSPORTER ABCA12; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:ELW49201.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 868..891
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 912..934
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 946..970
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 977..997
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1051..1072
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1776..1798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1829..1851
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1857..1876
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1888..1912
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1975..1996
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1150..1387
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 2043..2283
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 525..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1493..1519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2333..2353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1493..1517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2353 AA; 266233 MW; ED72FDAE2CB1AF66 CRC64;
MASQFHQLRI LVWKNWLGVK RQPLWTLVLI LWPVIIFIIL AITRTKFPPT AKPTCYLAPR
NLPSTGFFPF LQTLLCDTDS KCKDTPYGPQ DLLRRKGLDD AQFKDSEILR KSSNRETDSN
LSLQSTQVPE RTHASLATVF PSPSSDLESA RTDTFNGSQV LARILGLEKL LKQNSTSEDI
RRELCEDYPG YTENYAFSWT SLGKNVFNKF CLSNMTLLES SLQELQKQFS QVSRDPNNQK
VVFQEMVKVL SFFSQVQEQT AVWQLLSSFS SVLQNDTSIT NLFDVLRKAN RALLVIQKVY
PRVATNEGFR TLQKTVKHLL YTLDSPVQEN LRLLQSTIRF KKSFLQNGSY EDYFPPVPEV
LKSKLSQLRN LTELLCESET FNSMEKSCQL SNMSFGNLCE ESVFHVQLLE AAELGTDIAT
SLLYHDNVLS KKLRDLLTGD PSKINLNMDQ FLEQALQMNY LENITRLIPT IEAMLHVNNS
AVASEKPGHL VEMFKNVEEL KKELRTTGMS NTSIEKLLAI PIPENRAEGR SKASRKDDRA
LHKAERDSQS DGFGHTSAAR QNEIPETNAS AQKCSINTAP FCFSLYKDII NMPAGPVIWA
FLKPMLLGRI LYAPYNPITK AIMEKSNVTL RQLAELREKS QEWMDKSPLF MNSFTLLNQA
IPMLQTTLRN PFVQVFVKFS VGLDAVELLK QIDELDILRL KLENNIDIID QLNTLSSLTV
NISSCVLYDR IQAATTIDEM EREAERLYKR NELFGSVIFK LPSNRSRHRG YDSENVFLPP
IIKYTIRMSL KTAQTTRSIR TKIWAPGPHN SPSHNQIYGR AFIYLQDSIE RAIVELQTGR
NSQEIAVQVQ AIPYPCFMKD NFLTSVSYSL PIVLMVAWVV FIAAFVKKLV YEKDLRLHEY
MKMMGVNSCS HFFAWLIESV GFLLVTIAIL IVILKFGNIL PKTNGFILFL YFSDYSFSVI
AMSYLISVFF NNTNIAALIG SLIYIIAFFP FIVLITVENE LSYVVKVFMS LLSPTAFSYA
SQYIARYEEQ GIGLQWENMY SSPVQDDTTS FGWLCCFILA DSFIYFLIAW YVRNVFPGTY
GMAAPWYFPI LPSYWKERFG CAEMKREKSN GLMFTNIMMQ NTNPSASKTS PEYMFPSNIE
PEPKDLTVGV ALHGVTKIYG SKVAVNNLNL NFYEGHITSL LGPNGAGKTT TISMLTGLFG
ASAGTIFVYG KDIKTDLHTV RKNMGVCMQH DVLFSYLTTK EHLLLYGSIK VPHWTKKQLH
EEVKRQVTTG MTLKDTGLYS HRHKRVGTLS GGMKRKLSIS IALIGGSRVV ILDEPSTGVD
PCSRRSIWDV ISKNKTARTI ILSTHHLDEA EVLSDRIAFL EQGGLRCCGS PFYLKETFGD
GYHLTLTKKK SPNLSANTAC DTMAVTTMIR SHLPEAYLKE DIGGELVYVL PPFSTKVSGA
YLSLLRALDN GMGDLNIGCY GISDTTVEEV FLNLTKESQN NSDMRLEHLT QKNIGIPSTN
GTSTPDDLSV SSSSFTDRDD KTLTRGERLT GFRLLLKKIM AILIKRFHHT RRNWKGLIAQ
VILPIVFVTT AMGLGTLRDT SNSYPEIQIS PSLYGTSEQT AFYARCLKKD SLEKWDTSGE
RITNFGVCSC SENVQECPKF NYSPPHRRTY SSQVIYNLTG HRLENYLIST ANAFVQKRYG
GWSFGLPLTK DLRFDVTAVP ANRTLAKVWY DPEGYHSLPA YLNSLNNFLL RINMSEYDAA
RHVLVMNLFE RKRAAKTYVC FPLPIAHYRI SSLIDILVAL SILMGYSVTT ASFVTYVVRE
HQTKAKQLQH ISGIGVTCYW VTNFIYDMVF YLVPVAFSIG VIAIFKLPAF YSENNLGAVS
LLLLLFGYAT FSWMYLLAGL FHETGMAFIT YVCVNLFFGI NSIVSLSVVY FLSKEKPNDP
TLELISETLK RIFLIFPQFC FGYGLIELSQ QQSVLDFLKA YGVEFPSETF EMDKLGAMFV
ALVSQGTMFF LLRLLINEWL IKKLRLFFRK FVSSPVMETI DEDEDVRTER LRVESGAAEF
DLVQLHRLTK TFQLIHKKII AVNNISLGIP AGECFGLLGV NGAGKTTIFK MLTGDIIPSS
GNILIRNKAG SLGHVDSHSS LVGYCPQEDA LDDLVSVEEH LYFYARVHGI PEKDIKETVH
KLLRRLHLMP YKDRPTSMCS YGTKRKLSTA IALIGKPSIL LLDEPSSGMD PKSKRHLWKI
ISEEVQNKCS VILTSHRFGR GFTVKVHLKN NKVSMETLTR FMQLHFPKTY LKDQHLSMLE
YHVPVTAGGV ANIFDLLETN KTALNITNFL VSQTTLEEVF INFAKDQKSY ETADTSSQSS
TISVDSQDDR IES
//
