ID L9JH18_TUPCH Unreviewed; 927 AA.
AC L9JH18;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Gamma-glutamyltranspeptidase 1 {ECO:0000313|EMBL:ELW49648.1};
GN ORFNames=TREES_T100005558 {ECO:0000313|EMBL:ELW49648.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW49648.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SIMILARITY: Belongs to the gamma-glutamyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009381}.
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DR EMBL; KB320991; ELW49648.1; -; Genomic_DNA.
DR AlphaFoldDB; L9JH18; -.
DR STRING; 246437.L9JH18; -.
DR eggNOG; KOG2410; Eukaryota.
DR InParanoid; L9JH18; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0036374; F:glutathione hydrolase activity; IEA:InterPro.
DR GO; GO:0006751; P:glutathione catabolic process; IEA:InterPro.
DR Gene3D; 1.10.246.130; -; 1.
DR Gene3D; 3.60.20.40; -; 3.
DR InterPro; IPR043138; GGT_lsub_C.
DR InterPro; IPR000101; GGT_peptidase.
DR InterPro; IPR043137; GGT_ssub.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR PANTHER; PTHR11686; GAMMA GLUTAMYL TRANSPEPTIDASE; 1.
DR PANTHER; PTHR11686:SF56; GLUTATHIONE HYDROLASE 1 PROENZYME-RELATED; 1.
DR Pfam; PF01019; G_glu_transpept; 2.
DR PRINTS; PR01210; GGTRANSPTASE.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 2.
DR PROSITE; PS00462; G_GLU_TRANSPEPTIDASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 171..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 601
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR600101-1"
SQ SEQUENCE 927 AA; 98679 MW; A91ECFC9D57F6B8C CRC64;
MVQKSRAGQL GRGLAFVVGP GLTPSLHASV SLALVSRLLR AKHLQADLSP RDGQVVMQLL
QGTWVEREVA RGRGRAGTGN HVTQTHRSPL PLLCGQYCPG ATLAMQVSSL ANLRDGPACP
PQGQGTVSFL DLEVGGACWR AARQEVVRVA FPTLWVTVLL RGFDRAMKKR FVALGLLAVV
LVLVIIGLCV WLPSASKQPE TPGQLSPQMP SAALRLAGQA EVDGWVARGA LWVVRGGQGG
HTSPPTWRGR DMLREGGSAV DAAIAALLCV GLMNAHSMGI GGGLFLTIYD SATRKAEIIN
AREVAPGLAS ANMFNNSQQS QEGGLSVAVP GEIRGYELAH KRHGRLPWAR LFEPSIQLAR
GGFPVGKGLA GALERSRATI ERRPALCEVF CKNGKVLQEG ETLTLPRLAD TYETLAREGP
QAFYNGSLTA QIVKDIQAAG GIVTAKDLSE YRAELIEHPL NVSLGDMVLY VPSAPLSGPV
LALILNILKG TGTRSVSYRN LVDAKGVVRR GRGVGYKFSQ ASVATPEQKG LTYHRIVEAF
RFAYAKRTLL GDPKFINVTK VVRNMSSEFF AAQLRDRISD DTTHQASYYE PEYYTPDDGG
TAHLSVVAED GSAVSATSTI NLYFGSKVRS QTSGILFNDE MDDFSSPNIT NQFGVPPSPA
NFIKPGKQPL SSMCPAIIVG PDGRVQMVVG ASGGTQITTA TALVRSQTSG ILFNDEMDDF
SSPNITNQFG VPPSPANFIK PGKQPLSSMC PAIIVGPDGR VQMVVGASGG TQITTATALA
IIHSLWFGYD VKQAVEEPRL HNQLLPNTTT LERDMDQDVQ GPAQLSDKAH PAQGSHLTLP
GRLAGNSTHW VCEAHDHSGA AWTVSGAPLR PSPVPSDPQA VITALRTRNH QTQITSTFIA
VVQAVVRTAG GWAAASDSRK GGEPAGY
//
