ID L9JH79_TUPCH Unreviewed; 448 AA.
AC L9JH79;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Sodium/glucose cotransporter 1 {ECO:0000313|EMBL:ELW49659.1};
GN ORFNames=TREES_T100005549 {ECO:0000313|EMBL:ELW49659.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW49659.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC {ECO:0000256|ARBA:ARBA00004673}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004434}.
CC -!- SIMILARITY: Belongs to the cytochrome c oxidase IV family.
CC {ECO:0000256|ARBA:ARBA00008135}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000256|ARBA:ARBA00006434, ECO:0000256|RuleBase:RU362091}.
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DR EMBL; KB320991; ELW49659.1; -; Genomic_DNA.
DR AlphaFoldDB; L9JH79; -.
DR STRING; 246437.L9JH79; -.
DR InParanoid; L9JH79; -.
DR UniPathway; UPA00705; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IEA:InterPro.
DR Gene3D; 1.10.442.10; Cytochrome c oxidase subunit IV; 1.
DR Gene3D; 1.20.1730.10; Sodium/glucose cotransporter; 2.
DR InterPro; IPR004203; Cyt_c_oxidase_su4_fam.
DR InterPro; IPR036639; Cyt_c_oxidase_su4_sf.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR NCBIfam; TIGR00813; sss; 1.
DR PANTHER; PTHR11819:SF110; GENE 5134-RELATED; 1.
DR PANTHER; PTHR11819; SOLUTE CARRIER FAMILY 5; 1.
DR Pfam; PF02936; COX4; 1.
DR Pfam; PF00474; SSF; 2.
DR SUPFAM; SSF81406; Mitochondrial cytochrome c oxidase subunit IV; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 61..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 448 AA; 49392 MW; 41DFE4221EA606B2 CRC64;
MPRGSSQNAL RGTSEPLPPP VQAARIARPG NATMDRKHQG IASNWSSMGI GVHSPLDSLV
LSVYLLLVVG VGLKIGISLF ATNIGIGHLM GLAGIGASSG IAAGAFEWNV VTLPEYLRKR
FGGFRIQLLL CILYLFLYIF NRILLEICSG AIFLRMVWGM DVYLSTMVLL TIAGMYTITA
FSEVEGYEGL LKKFFHAIPS VVSDGNWTAD PQCYIPRPDS FHIFRDAISG DFPWPGMVFG
ISILSLYYWC ADQVFVQRCL AAKNTSHVKG SCILCGYLKL LPMFTIVMPG MISRIMSPDR
VACVVPSECY KYCGSTVGCN PSAYPELVVE LLPSGIRGLM LCALCASLMS SLTSVFNSCS
ALFTLNIYHR LRPVATEKEL MVTGSQKALK EKEKASWNSL SGHEKGPILH TFNKDWVATQ
TKRVLDMKVS PIQGFSTRWD YDKNEWQM
//
