ID L9JQL1_TUPCH Unreviewed; 416 AA.
AC L9JQL1;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Neuropeptide Y receptor type 5 {ECO:0000256|ARBA:ARBA00019481};
DE AltName: Full=NPY-Y5 receptor {ECO:0000256|ARBA:ARBA00032994};
GN ORFNames=TREES_T100017916 {ECO:0000313|EMBL:ELW52806.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW52806.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- FUNCTION: Receptor for neuropeptide Y and peptide YY. The activity of
CC this receptor is mediated by G proteins that inhibit adenylate cyclase
CC activity. Seems to be associated with food intake. Could be involved in
CC feeding disorders. {ECO:0000256|ARBA:ARBA00024704}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB320953; ELW52806.1; -; Genomic_DNA.
DR AlphaFoldDB; L9JQL1; -.
DR STRING; 246437.L9JQL1; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; L9JQL1; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004983; F:neuropeptide Y receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000393; NPY5_rcpt.
DR InterPro; IPR000611; NPY_rcpt.
DR PANTHER; PTHR24235; NEUROPEPTIDE Y RECEPTOR; 1.
DR PANTHER; PTHR24235:SF10; NEUROPEPTIDE Y RECEPTOR TYPE 5; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01016; NRPEPTIDEY5R.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:ELW52806.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 115..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 189..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 131..395
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 416 AA; 46063 MW; 9FA6EE628F9A492D CRC64;
MTVTTTSLAP LQQPLLSSPE FEGREKRQCR VLRTNLEQAG RGTDIYLHLF NASETCEEKV
FLVLQAKESP LGCKMDSELR EHNSTLAAEN ASAAPGRAGF PVWEDFRGSV DDLQYFLIGL
YTLVSLLGFV GNLLILMALV KRRHQQTTVN FLIGNLAFSD ILVVLFCSPF TLASVLLDRW
LFGRVLCHVV PFLQCVSVLV STLILMAIAV VRYHTVRRPL SSSLTANHGY FLIAAVWTLG
LALCAPLPVF HRLVELRDTV GAVVCVEACP SSAYRVAFTL SLLLAQYVLP LLLGSNAKVV
PGVPTCFEVK AEENSDGPQP RAQRSATRIR KRSRSVVYRL TVLILVFAVS WMPLHLFHVV
TDFNDSLISN RHFKLVYCVC HLLGMTSCCL NPLLYGFLNN GVKADLLSLT PCLHVS
//
