ID   L9JVI3_TUPCH            Unreviewed;      1409 AA.
AC   L9JVI3;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Interferon-induced GTP-binding protein Mx1 {ECO:0000313|EMBL:ELW53212.1};
GN   ORFNames=TREES_T100017892 {ECO:0000313|EMBL:ELW53212.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW53212.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23385571; DOI=10.1038/ncomms2416;
RA   Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA   Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA   Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA   Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA   Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT   "Genome of the Chinese tree shrew.";
RL   Nat. Commun. 4:1426-1426(2013).
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. Dynamin/Fzo/YdjA family. {ECO:0000256|RuleBase:RU003932}.
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DR   EMBL; KB320951; ELW53212.1; -; Genomic_DNA.
DR   STRING; 246437.L9JVI3; -.
DR   eggNOG; KOG0446; Eukaryota.
DR   InParanoid; L9JVI3; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0009615; P:response to virus; IEA:UniProt.
DR   CDD; cd08771; DLP_1; 2.
DR   Gene3D; 1.20.120.1240; Dynamin, middle domain; 3.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR022812; Dynamin.
DR   InterPro; IPR001401; Dynamin_GTPase.
DR   InterPro; IPR019762; Dynamin_GTPase_CS.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR000375; Dynamin_stalk.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR003130; GED.
DR   InterPro; IPR020850; GED_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11566; DYNAMIN; 1.
DR   PANTHER; PTHR11566:SF217; INTERFERON-INDUCED GTP-BINDING PROTEIN MX1; 1.
DR   Pfam; PF01031; Dynamin_M; 3.
DR   Pfam; PF00350; Dynamin_N; 2.
DR   Pfam; PF02212; GED; 2.
DR   PRINTS; PR00195; DYNAMIN.
DR   SMART; SM00053; DYNc; 2.
DR   SMART; SM00302; GED; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00410; G_DYNAMIN_1; 2.
DR   PROSITE; PS51718; G_DYNAMIN_2; 2.
DR   PROSITE; PS51388; GED; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|RuleBase:RU003932};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU003932};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT   DOMAIN          90..363
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51718"
FT   DOMAIN          761..1034
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51718"
FT   DOMAIN          1321..1409
FT                   /note="GED"
FT                   /evidence="ECO:0000259|PROSITE:PS51388"
SQ   SEQUENCE   1409 AA;  161327 MW;  FC4840E185341A32 CRC64;
     MNASQQQPSA FGTAPKPVVF SPKWQFGEKD TIFLAKDFNF LSLNQQQPAG NKIFQVAKGS
     ENKLFSQYEE KVRPCINLID SLRTLGVEQD LALPAIAVIG DQSSGKSSVL EALSGVALPR
     GSGIVTRCPL VLKLMKQSQE PVWRGKIRYR NTEKKLGDPT QVEAEICKAQ NIIAGSGVGI
     SHELITLEIT SPEVPDLTLI DLPGITRVAL GNQPQDISLQ IKALIKKYIK RQQTINLVVV
     PCNVDIATTE ALSMAQEVDP EGDRTLGILT KPDLVDKGSE KSVMNVLQNL TFPLKKGYMI
     VKCRGQQEIM NNLSLAEATR KELMFFQSHP HFRVFLEEKK ATVPHLAERL TAELIAHIRK
     SLPSLESEIR ERHQGATEEL RRCGADIPTQ ETDKMFFLIE KIKVFNQDVE KLVEGEEIVR
     EKETRLYNKI REEFKNWVLV LAANTQKVKN IIHEEVSKYE KQYRGKELPG FVNYKTFQNI
     VQQYIQQLVN PALDMLQKIV ELVQEAFIVT AQNNFGEFAN LNRTAQSKIE DIKIKQAEKA
     ENMIQLQFQM EKLVYCQDQI YSVVLKKVRE ELFNPVEKPS HNIHPNSCVI NDLSPVSAIT
     EIGVHLNAYF SETSKRLANQ IPFIIQFFVL QDNGNWLQKA MMQILQEKER YSWLLQEQVL
     APFKAEERVE RLHSLLRWER KKMVHSEAEV IKPDSVSEAS FLLLNGDVDV AEKQVKKTDN
     NLCSQYEEKK TDNNLCSQYE EKVRPCIDLI DSLRALGVEQ DLALPAIAVI GDQSSGKSSV
     LEALSGVALP RGSGIVTRCP LVLKLKKLIN EDKWRGKVSY QDIEVEITDP SKVEPEINKA
     QNVIAGEGMG ISHELISLEV SSPHVPDLTL IDLPGITRVA VGNQPADIGR QIKTLIKKYI
     HKQETINLVV VPSNVDIATT EALSMAQEVD PDGDRTIGIL TKPDLVDKGT EEKVVDVVRN
     LVCHLKKGYM IVKCRGQQDI QDRLSLAEAL QREKVFFEEH PYFSFLLEEG KATIPCLAER
     LTTELIMHIS KSLPLLENQI KESHQKITEE LKKYGTDIPE DENEKMFFLI DKINTFNQNI
     MVLIQGEEIV GEDDTRLFTK LRNEFHKWNI MIEKNFQKGY DLIRKKIWKF ENQYRGRELP
     GFVNYRTFES IIKEQIKALE EPAIDMLHTV TGYDLIRKKI WKFENQYRGR ELPGFVNYRT
     FESIIKEQIK ALEEPAIDML HTVTDMVRLT FTDASVKNFD EFFNLHRTAK SKIEDIRLEQ
     EKEAEKSIRL HFQMEQIVYC QDHVYRSALQ KVREKETEEE KKTKTPVVTF SQQLSSTESS
     MAEIFQHLTA YQQEASNRIS SHIPLIIQFF ILQTFGQQLQ KGMLQLLQDK DAYNWLLKER
     SDTSDKRKFL KERLSRLAQA RRRLAKFPG
//