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Database: UniProt
Entry: L9K1Y8_TUPCH
LinkDB: L9K1Y8_TUPCH
Original site: L9K1Y8_TUPCH 
ID   L9K1Y8_TUPCH            Unreviewed;      3104 AA.
AC   L9K1Y8;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   02-DEC-2020, entry version 29.
DE   SubName: Full=Centromere protein F {ECO:0000313|EMBL:ELW55467.1};
GN   ORFNames=TREES_T100017246 {ECO:0000313|EMBL:ELW55467.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW55467.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23385571; DOI=10.1038/ncomms2416;
RA   Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA   Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA   Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA   Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA   Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT   "Genome of the Chinese tree shrew.";
RL   Nat. Commun. 4:1426-1426(2013).
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DR   EMBL; KB320929; ELW55467.1; -; Genomic_DNA.
DR   RefSeq; XP_006155889.1; XM_006155827.2.
DR   RefSeq; XP_006155890.1; XM_006155828.2.
DR   RefSeq; XP_006155891.1; XM_006155829.2.
DR   STRING; 246437.XP_006155889.1; -.
DR   GeneID; 102487040; -.
DR   KEGG; tup:102487040; -.
DR   CTD; 1063; -.
DR   eggNOG; ENOG502QVMD; Eukaryota.
DR   InParanoid; L9K1Y8; -.
DR   OrthoDB; 205405at2759; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:InterPro.
DR   GO; GO:0070840; F:dynein complex binding; IEA:InterPro.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR   GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 2.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 2.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT   DOMAIN          1..305
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          2126..2265
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2308..2447
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2964..3007
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          212..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..276
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1230..1260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1520..1539
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2886..2976
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3021..3104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..85
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          97..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          164..198
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          278..340
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          348..382
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          391..457
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          472..495
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          521..555
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          577..628
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          735..755
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          835..855
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          895..988
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1024..1079
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1120..1150
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1281..1315
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1327..1354
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1384..1404
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1544..1596
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1621..1641
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1786..1844
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1892..1912
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1927..1947
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1969..1989
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1997..2080
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2102..2129
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2137..2280
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2319..2339
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2354..2433
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2435..2490
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2498..2539
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2550..2598
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2606..2679
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2683..2710
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2712..2767
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2775..2819
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2827..2857
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2865..2885
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        2886..2948
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2949..2976
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3023..3070
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3104 AA;  356826 MW;  8E7E532F68E27808 CRC64;
     MSWALEEWKE GLPTRALQKI QELEGQLDKL KKEKQQRQFQ LETLEAALQK QKQKVENEKT
     EGTNLKRENQ RLMEICENLD KSKQKISHEL QIKESQVNFQ EGQLNSSKKQ IEKLEQELKR
     CKSELERSQQ MAQSADVSLN PCSTPQKMFT TPLTPRQCYS GSKYEDLKEK YNKEVEERKR
     LEAEVKALQA KRTSQTISQS TMNHRDIARH QASSSVFWQQ ETPGRLSSDS HRTPAGRDFS
     ASHFLRDHEV TPSKLTSKIG KRDANNAACD NSSSPHLLDQ LKAQNKELRS KINELELHLQ
     GQEKEIKGQA NKFQEVQLQL EKAKVDLIEK EKVLNKNRDE LVRTTAQYDQ ASTKCTTLEQ
     KLKKLTEDLN CQRQNAESAR CSLEQKIKEK EKEFHEELSR QQRSLQTLDQ ECTQVKAKLT
     QELQQAKNTQ NILQAELDKA TLVKQQLERS LEEFKQKCCR TEQALQARQV TEDELRRSSE
     EMKKENGLLK RQSEQRAREV CHLEEELKKV KQCLNQSQNF VEEMRAKNLS QETMLRELEE
     KVNLQENSLT LEKLKVSTAD LEKQQDQDLL KKREYHIEQL NYKLSKTEEE YKALLSTLEL
     MKKEYKKLEE EKALFSSWKS ENEKLLNQMA LEKESSQSKI NHLETLLNTH QIKSHEYDEK
     VRTLQMERES LNVEIRNLHS VIDSKSVEIE TQKQAFVELQ QKAEVSDEKH NKEIENMCLK
     TSQLTGQVED LGHKLQLLSS EIMDKDQQYQ DLHAEYEGLR DLLKSKDSFL VTNEDHQRSL
     LAFKQQSDKN DSFAKIRGEQ ECMPSEKSEC NLEVDQSPKN SAILQNRVVS LEFLLESQKQ
     MNSDLQKQCE ELVQIKGEIE GNLIKAEQMH QSFVAETSQR ISKLQEDTSL HQNVVAETLV
     ALENKEKEFQ LLNEKLETEQ AEVQELKKSN YLLENSVKEL QLLCETLSSE KKELSSVISL
     HKKQIEELTQ ENGALKEINE TLNQEKANFV QKSDSFSNSI DEKERISEFS DQFKHERLTL
     LQRCEETRNA FEDLSQKYKA AQEKNSKLEC LLNECTSICE NKKMELEQLK EIFAKEHKEF
     LTKLALAEER NQVLILELGT VQQDRQSEIA HIQNNFKSET DGLNQEIMIL KEQQNKMQKE
     DNGLLQENEE LKKLMHTKHE HQNLEVDPIR DSMKDSKNEI NKHNCQRQVD LEVKDLFLDS
     YNTQLVHLEA MVRNLEVKLL ESENEKECLQ QELQRTRGES ETKSSQDTQS QEISNLKDCE
     KDTEEKYISV LHELSTSQND NAHLQCSLQT AMNKLNELEK MYEILQIEKL ELVSELNDSR
     SEYITVTNKM TEEVEKLVNE VKILNDKNSH LQGDLVTEMA EGEFGEQQNE KSVSLNPMED
     SNSYERLTLS NKEVQTHFAE LQEKFLSLQG EHKILHDQHC QMSSKMSELQ TYVDKLKAEN
     SVLSVNLRNV QGDLVKEMKP GPEEEQILSP SFSCVTDSPN LTRFGEGSLD KDLLEQTGET
     SLWSDLEGNV SANQSNVGEV SCSSLEEEEN LTKKETSSAP VRSVEELEIL CQMYLQSLKN
     LEEKMENQGI LKNKEIQELE QLLSSERKEL DCLRKQFLSE NEQWQQKLTS VTMEMESKLA
     AEKKQTEHLS MELEVARLQL QGLDLSSRSF IGTDTDVVRG QNESCDITES DEYTSETTER
     IPKQDICQIC DENNQQDLSL ETREITETET VKLRGECCKE QSPETNCDVP VEDKPQGCPE
     CISQLSLSGP SALVPVNALG DQVTIQNLQL QVEETLSENL RLLHVLEDRD KKVESLLNEK
     RELSAKLDLQ EVQLTNKIEA CIALEKILEE LKEKSDLSEK LESVSCDNQE LYQRVDTSDS
     MNPHLEMGPN KLSDEVIDDS VAKVDDNCKK SLLDMENELN RIKSEKASIE CHALSMEADL
     EIVQTEKLCL EKDNESKQKV IVSLEEELLV VTRERNRLHG ELDTVSKDNK ELVGVSEKLK
     ERVQELESHQ GACVDRIQVV EAELKDKTEL LQTLSSDVSG LLKDKTHLQE QLQSLEEDSQ
     ALSLVKRELE NQIGQLNKEK ESLLRKFESL QARLSELEHD KLNVSKALEA ALIEKGEFAG
     KLSSTQEEVH QLRRGIEKLR VRIEADEKNQ LHVVEKLKER ERENDSLKDK VESLERELQM
     SEENQELVIL DAENSKAEVE TLKTQVEEMA KSLKVLELDH GKVRSEKENL TEQLQEKQDQ
     VSELDKMVSS FKSLLKEKEQ AEIQMKEEAK TIVEMLQTQL KELNEEVKAL YNDQEGWKAE
     EPSPDTPVED VDKKINSIEK LKALIETDGK KQRLVIEKLK ESQHSADLLK DRVGNLEREL
     DISGKNQESA VLEAENSKAM VETLKARIEK TDQNLSDLEL ALTDIRLEKE NLMKEKQKEQ
     ERVSELETLS SSLENLLREK EQQNVQLREE STVAIEMVQA KFQELSEKVS DLCNDQEIYK
     AKVQNLSNQV NSLETEKAKL LQDLNKAKNN DSVLQSTVKD LIREVEDGKQ KVEKKDEEIS
     RLNSQIQDQE QLLSKLSQVE GEQELCKKQN VELRNLTVEL EQKIQVLQSQ NATLQNTVEA
     LQNSYKDIEN QLELTKTEKM SFAEKVNTMT AKESELQREI REMVQKRTDL EEEFSGEKNK
     LTKELKLLLE EIQSNKGQLK ELMLENSELK KSLDCVHKDQ VEKEEKVREV TEYQLQLQEA
     EKRHQTLLLD TNKQYQIEIQ TYQEKLTSKE ECLKSQKLEI DNLKSTKEEL NNSLKVTTQL
     VEELKKAKVD NLKYVSQLKK ENERAQGKIK LLMKSCKQLE EEKGMLQKEL SQLEAALEKQ
     KTGTIVNPNL DELMTEMKEL KETLEEKSKE ADEYLDKYCS LLISHEKSEK AREMLETQVA
     RLSSQLSKHD LRSSPSLNSV VPGPSPVSSV PEKKLSSGQN KTSGKRQRPS GISDNDGGSV
     PSTPETFSKK SRKIVKSVPH SASDTEDTEF EPEGLPEVVK KGFADIPVGK TSPYILRRTT
     MATRTSPRLA AQKLALSPLS LGNKILVDSS KRTAGGSRSQ KVKIAQQSPV DSGTAFREPT
     TRSLAVNNLS GDSPREGLRV KRGQLTPSPE AGPEPKGSEN CRVQ
//
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