ID L9K2W8_TUPCH Unreviewed; 530 AA.
AC L9K2W8;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Legumain {ECO:0000256|ARBA:ARBA00021147};
DE EC=3.4.22.34 {ECO:0000256|ARBA:ARBA00012628};
DE AltName: Full=Protease, cysteine 1 {ECO:0000256|ARBA:ARBA00030799};
GN ORFNames=TREES_T100017213 {ECO:0000313|EMBL:ELW55812.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW55812.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins and small molecule substrates at
CC -Asn-|-Xaa- bonds.; EC=3.4.22.34;
CC Evidence={ECO:0000256|ARBA:ARBA00000810};
CC -!- SIMILARITY: Belongs to the peptidase C13 family.
CC {ECO:0000256|ARBA:ARBA00009941}.
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DR EMBL; KB320925; ELW55812.1; -; Genomic_DNA.
DR AlphaFoldDB; L9K2W8; -.
DR STRING; 246437.L9K2W8; -.
DR MEROPS; C13.004; -.
DR InParanoid; L9K2W8; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IEA:InterPro.
DR CDD; cd21115; legumain_C; 1.
DR Gene3D; 1.10.132.130; -; 2.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR043577; AE.
DR InterPro; IPR048501; Legum_prodom.
DR InterPro; IPR046427; Legumain_prodom_sf.
DR InterPro; IPR001096; Peptidase_C13.
DR PANTHER; PTHR12000; HEMOGLOBINASE FAMILY MEMBER; 1.
DR PANTHER; PTHR12000:SF42; LEGUMAIN; 1.
DR Pfam; PF20985; Legum_prodom; 2.
DR Pfam; PF01650; Peptidase_C13; 1.
DR PIRSF; PIRSF500139; AE; 2.
DR PIRSF; PIRSF019663; Legumain; 2.
DR PRINTS; PR00776; HEMOGLOBNASE.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 374..439
FT /note="Legumain prodomain"
FT /evidence="ECO:0000259|Pfam:PF20985"
FT DOMAIN 437..526
FT /note="Legumain prodomain"
FT /evidence="ECO:0000259|Pfam:PF20985"
FT ACT_SITE 188
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT ACT_SITE 229
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
SQ SEQUENCE 530 AA; 59714 MW; 63748BC177496B11 CRC64;
MGVMGNAFTI QCQARPSPGL PEGVRVLRRS RLLQLHTKGD MIWKVAVLLG AVLGTGAMFL
DDPEDGGKHW VVIVAGSNGW YNYRHQADAC HAYQIIHRNG IPDEQIIVMM YDDIANSEDN
PTPGIVINRP NGTDVYKGVL KDYTGEDVTP QNFLAVLRGD AEAVKGKGSG KVLKSGPKDH
VFVYFTDHGA TGLLAFPNDD LHVKNLSETI RYMYKHKMYQ KMVFYIEACE SGSMMNHLPD
DINVYATTAA NPDESSYACY YDEERNTYLG DWYSVNWMED SDVEDLTKES LHKQYRLVKS
HTNTSHVMQY GNKSISAMKL MQFQGMKHKA STPISLPPVT HLDLTPSPEV PLAIMKRKLM
RTNDLQESKK LAEEIQRHLE VRNVIAVSVR KIVSLLAASE AEVEGLLSQR APLTEHDCYQ
AAVAHFRTHC FNWHSATVRN VIAVSVRKIV SLLAASEAEV EGLLSQRAPL TEHDCYQAAV
AHFRTHCFNW HSATYEYALR HLYVLVNLCE KSYPVDRIKL SMDKVCLGYY
//
