ID L9KHS7_TUPCH Unreviewed; 904 AA.
AC L9KHS7;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Solute carrier family 2, facilitated glucose transporter member 8 {ECO:0000313|EMBL:ELW62024.1};
GN ORFNames=TREES_T100004262 {ECO:0000313|EMBL:ELW62024.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW62024.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB320843; ELW62024.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KHS7; -.
DR STRING; 246437.L9KHS7; -.
DR eggNOG; KOG3686; Eukaryota.
DR InParanoid; L9KHS7; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR48021; -; 1.
DR PANTHER; PTHR48021:SF18; SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 8; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00083; Sugar_tr; 2.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 2.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Sugar transport {ECO:0000313|EMBL:ELW62024.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000313|EMBL:ELW62024.1}.
FT TRANSMEM 473..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 500..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 559..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 684..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 718..740
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 747..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 797..823
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 835..852
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 864..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 397..890
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 184..211
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..314
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 904 AA; 96237 MW; 64AAA4C10D8FF5DD CRC64;
MGVCSYGPAM IPQAMRGPQL LHKFSDITWH ISWSVIACIL AISAADSKVT LWKEADDGQW
MCISSVHKGQ VNFVAAIDVY EDGEAGVLLC YNYSCIYKKV CPFNGGSFLV QPSASDFQFC
WNQAPYAIVC AFPYLLAFTT DSMEIRLVVN GNLVHTAVVP QLQLVASRSD IYFTATAAVN
EVSSGGSSKG ASAHSSPQTP PGRDAPVLPS SLGEGEIQSK NLYKIPLRNL VGRSIERPLK
SPLVSKAITP PTSISLGIAA IPVTHSLSLS RMEIKEIASR TRRELLGLSD EGGPRTEGVP
KAKSKARKRL EESQGGPKPG TVRSSSSDRI TSGSLESPST SEANPAGHIH LTASDRDPAA
DREGSPVSSS SPFQLLASSD DDIIDLNAPR GRRVFLAAFA AALGPLSFGF ALGYSSPAIP
SLRRAALPAL RLDDNAASWF GLGIPMLSFR GRRGGLEGED GRPPLALLSQ QTLSPQAIVT
LGAAAGGVLG GWLVDRAGRK LSLLLCTLPF VAGFTIITAA QDMWMLLGGR LLTGLACGVA
SLVAPVYISE IAYPAVRGLL GSCVQLMVVL GILLAYLAGM LLLMCCMPET PRCLLTQHKR
QEAMAALQFL WGSVQGWEEP PRAEHQAGLG QDAEAHFPPP CCDSGLSEVG TQRGEREALM
AGPGLVEQGF HLGLLRHPGI YKPFVIGISL MAFQQLSGVN AIMFYADTIF EEARFKDSSL
ASVVMGVIQV LFTAAAALIM DRAGRRLLLT LSGAVMVFST SAFGAYFKLA QGGPGNSSQV
DFLAPVSAEP TDTSVGLAWL AVGSMCLFIA GFAVGWGPIP WLLMSEIFPL HVKGVATGVC
VLTNWLMAFL VTKEFSSLME ALRPYGAFWL ASAFCIFAVL FTLFCVPETK GKTLEQITAH
FEGR
//
