ID L9KKU2_TUPCH Unreviewed; 722 AA.
AC L9KKU2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 22-FEB-2023, entry version 35.
DE SubName: Full=Melanophilin {ECO:0000313|EMBL:ELW63560.1};
GN ORFNames=TREES_T100020649 {ECO:0000313|EMBL:ELW63560.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW63560.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB320773; ELW63560.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KKU2; -.
DR eggNOG; ENOG502RJPZ; Eukaryota.
DR InParanoid; L9KKU2; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd15752; FYVE_SlaC2-a; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR037442; Melanophilin_FYVE-rel_dom.
DR InterPro; IPR006788; Myrip/Melanophilin.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14555:SF1; MELANOPHILIN; 1.
DR PANTHER; PTHR14555; MYELIN-ASSOCIATED OLIGODENDROCYTIC BASIC PROTEIN MOBP -RELATED; 1.
DR Pfam; PF02318; FYVE_2; 2.
DR Pfam; PF04698; Rab_eff_C; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50916; RABBD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 4..198
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT REGION 325..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 700..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..557
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..655
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 722 AA; 78362 MW; BB176932F6A9C778 CRC64;
MGKKLDLSKL TDEEAKHVWE VVQRDFDLRR KEEERLEPLT FVYLLGRSGL LRAWREGSIG
QIRRERSADH GRHSSLASAS PQALLCELPP SPPRPRSCSG AVLEPTLAKV RGLKGKMQKE
SSKRELLSET AHLNETHCAH CLRPFRLLVN SRRQCLDCSL FACKSCSRLH PEEQGWLCDP
CHLARVVKIG SLEWYHQHVR ARFKRFGSAK VIRSLSGRLQ KAGSPHGRQG SPDCGKCPEL
EWFGFNVLPV MESSPEISAP DRREDRMCFR VTRSIGPGNT GVTGCRGLTD PSCPLLALVQ
AVPCSRCACL VLAKKKRLLP IHASDLDADS DPTPPNGPAQ SPAADGLQSI VDEPCSEDED
EDEVGARAEG HHPGPGERPD SLLPPGRGTR AEPCPPGDPL RMTLGTPATP GIAVTMDEQP
PSHYLADVDT SEEESPWAPR AASQHARRRG RTASGSQGSV AGAHAEADDE EETLKRKLQE
LTSNVSDQGS SLEDEEGKDE EAEADSGYSV GALPRTGPKV CTVAGQMHTQ ERSPQSPGDP
AQPRRTTDEE LSELEDRGAA TASEVQQTES EVSDIESRIA ALRAAGLTVK PSGKPRRRSH
LPVFLPRVVG KSGKSPEEDP TAEVQGMAVP SLPRRKLNSS PKSHGREDES FHRKSVYRGS
LTQRNPNGRK GAASQVFAQV PGNGGGGGVC IRYNIVRAGT PGRHMGRERG LWTLQPSPTG
DG
//
