ID L9KLR6_TUPCH Unreviewed; 556 AA.
AC L9KLR6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Ras-GEF domain-containing family member 1B {ECO:0000313|EMBL:ELW63910.1};
GN ORFNames=TREES_T100007743 {ECO:0000313|EMBL:ELW63910.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW63910.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
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DR EMBL; KB320758; ELW63910.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KLR6; -.
DR STRING; 246437.L9KLR6; -.
DR InParanoid; L9KLR6; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 2.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF197; RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1B; 1.
DR Pfam; PF00617; RasGEF; 2.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 45..172
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 144..403
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 556 AA; 64175 MW; 74FAC29C68FCF393 CRC64;
MSQYSAPNQE SMPQTPPFSA MFDSSGYNRN LYQSAEDSCG GLYYHDNNLL SGSLEALIQH
LVPNVDYYPD RTYIFTFLLS SRLFMHPYEL MAKVCHLCVD HQRLSDSDGD KNQIRKIAPK
ILQLLTEWTE TFPYDFRDER MMRNLKDLAH RIASGEEQTY RKNVQQMMQC LIRKLAALSQ
YEEVLAKISS TSTDRLTVLK TKPQSIQRDI ITVCSDPYTL AQQLTHIELE RLNYIGPEEF
VQAFVQKDPL DNDKSCYSER KKTRNLEAYV EWFNRLSYLV ATEICMHQMD PSSNFYNYRT
ALRGAAQRSL TAHSSREKIV IPFFSLLIKD IYFLNEGCAN RLPNGHVNFE KFWELAKQVS
EFMTWKQVEC PFERDRKILQ YLLTVPVFSE DALYLASYES EGPENHVEKD RWKSLSDVQP
RKYCSEGRHD SILTCTLSHL RGRDIAFEAT VDAEAVEPGE WVLPCSRPPQ LQKLTETCVS
ESPHLLILLC DTDYCHPSAS PGAVADLLPS RGTESILLPK GLRPEDIEPK DFHKYPFIPY
TPTEHRHPRA GLHADS
//
