ID L9KM73_TUPCH Unreviewed; 1070 AA.
AC L9KM73;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN ORFNames=TREES_T100004151 {ECO:0000313|EMBL:ELW62242.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW62242.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR EMBL; KB320833; ELW62242.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KM73; -.
DR STRING; 246437.L9KM73; -.
DR eggNOG; KOG1959; Eukaryota.
DR InParanoid; L9KM73; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR Gene3D; 2.60.40.1360; -; 2.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF28; EPIDIDYMIS-SPECIFIC ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 2.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Signal {ECO:0000256|RuleBase:RU361199};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT CHAIN 19..1070
FT /note="Alpha-mannosidase"
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT /id="PRO_5017852351"
FT DOMAIN 367..450
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1070 AA; 122183 MW; 90FC02B8B4264B40 CRC64;
MGPLRWLLLL LQLQLLQAPE AGPAAPIRAF VVPHSHMDVG WVYTVEESMR AYAANVYTSV
VKELTLGKQR RFIAVEQEFF RLWWDGIASE QQKHQVRQLL DEGRLEFVLG GQVMHDEAVT
HIDDQILQLT EGHGFLYETF GVRPRFSWHV DPFGASATTP TLFALAGFNA HLISRIDYNL
KNAMQEAQGL QFLWQGSPSL AAQQIFTHVM DQYSYCTPSH IPFSNRSGFY WNGVAVFPNP
PPKGVYPNMS EPVTPANIRL YAEALVTNVK LRAAWFQTPH VLWPWGCDKQ FFNASVQFAN
MDPLLAHINS RAAELGVSVQ YATLGDYFRA LHALNVTWSV RDHRDFLPYS SVWLPCAQPI
SDREPLQAWT GFYTSRSALK GLARHAGALL YAGESLFTRY MWPAPLGTLD PAWALQQLQQ
LRWAVSEVQH HDAITGTESP KVRDMYEEHL AAGMLGVRKV MAAIILDRLR PAEQARQAAP
AVDSGPAGRS AVVYNPLAWT VTTIFTLTVG FPRVSVTDES GLPVPAQIQN STAIPSMYDL
HILTTIPGLS FRHYSIKPTS GVQKGSREPA ATVTRTLHFG RKLRRHASHR GKHLLHIVND
CYTVLLNQDT NLMQSIQDRQ SNRTVRVTQE FLEYHVNDDL TQGQLLSDNY MFTPKEAAVP
AWKAVGMEVV VGKLQTEIRQ YFYRNMAAQD YTYAIFTRLA HVPRGGDGEL LCHRIEQETS
TDLDSQRVIY SDNNGYQMQR RPYQAYAENS IARNYYPMVQ SAFIQDSRSR LVLLSERAHG
ISSQRTGQVE VMLHRRLWNN FYWDLNYNLT LNDTSVVRPV IWLLLGSWPV TTALRQRSAL
ALQHRPIVLF GELAATARKS PGPQQQEAVT LPPNLHLQIL SIPGWNYSSE HTEHMQNLKK
GHRGKAQADL RRVLLRLHHL YETGEDPVLS RPVTVNLKEV YMQEVYMQEV YMHEVYMQEV
YMQEVYMQEV YMQEVYVQEV YVQEVYMHEV YMHEVYMHEA LLHGLGSVVA VKERSLTGTW
DVSKLHRWSW RTKTGHHGGS HTSPLRPSGN PIVTIHPKEI RTFFIHFQQQ
//
