ID L9KMY1_TUPCH Unreviewed; 817 AA.
AC L9KMY1;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Actin filament-associated protein 1-like 1 {ECO:0000256|ARBA:ARBA00016930};
GN ORFNames=TREES_T100010710 {ECO:0000313|EMBL:ELW64310.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW64310.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- FUNCTION: May be involved in podosome and invadosome formation.
CC {ECO:0000256|ARBA:ARBA00002089}.
CC -!- SUBCELLULAR LOCATION: Cell projection, invadopodium
CC {ECO:0000256|ARBA:ARBA00004264}. Cell projection, podosome
CC {ECO:0000256|ARBA:ARBA00004188}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KB320740; ELW64310.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KMY1; -.
DR STRING; 246437.L9KMY1; -.
DR InParanoid; L9KMY1; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0002102; C:podosome; IEA:UniProtKB-SubCell.
DR CDD; cd13306; PH1_AFAP; 1.
DR CDD; cd13307; PH2_AFAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR030113; AFAP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR14338; ACTIN FILAMENT-ASSOCIATED PROTEIN 1 FAMILY MEMBER; 1.
DR PANTHER; PTHR14338:SF1; ACTIN FILAMENT-ASSOCIATED PROTEIN 1-LIKE 1; 1.
DR Pfam; PF00169; PH; 2.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 253..349
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 502..596
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 83..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 696..773
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 206..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..682
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 817 AA; 91610 MW; 6DF649751930C2B8 CRC64;
MPSPCVLEQL LPELTELLSL LDHEYLSDTT LEKKMAIASI LQSLQPLPAK EVSYLYVNTA
DLHSGPSFVE SLFEEFDCDL RDLRDMPEDD GEPSKVASPE PAKSPSLRIA ADLPPPLPIK
PPPEDYYEEA LPLGPGKSPE YISSHNGCSP AHSIVDGYYE DADSSYPATR MNGELKNSYG
CSPAHSIVDG YYEDADSSYP ATRMNGELKN SYNDSDAMSS SYESYDEEEE EGKSPQPRHQ
WPSEEASMHL VRDCRICAFL LRKKRFGQWA KQLTVIKEDQ LLCYKSSKDR QPHLRLALDV
CNVTYVPKDS RHKRHELRFS QGATEVLVLA LQSQEQAEEW LKVIREVSKP IGGAEGVEVP
RSPVLLCKLD QDKRLSQEKQ TSDSDSLGMS DSCSTLGRRE ACEHGKGKKS SLAELKGSMS
RAAGRKITRI ISFSKKKALA DDLQTSSTEE EVPCCGKGKK SSLAELKGSM SRAAGRKITR
IISFSKKKAL ADDLQTSSTE EEVPCCGYLN VLVNQGWKER WCRLKCNTLY FHKDRADLRT
HVNAIALRGC EVAPGFGPRH PFAFRILRNR QEVAILEASC SEDMGRWLGL LLVEMGSRVT
PEALHYDYVD VETLTSIVSA GRNSFLYARS CQDQWPEPRV YDDVPYEKIQ DEEPERPIGA
QVKRHASSCS EKSHRVDPQV KVKRHASSAN QYKYGKNRAE EDARRYLIEK EKLEKEKETI
RTELMALRQE KRELKEAIRN SPGAKLKALE EAVATLEAQC RAKEERRIDL ELRLVAVKER
LQQSLAGGPA LGLSMSSKNK SGSAFLSTFD LSDALLK
//