ID L9KMY6_TUPCH Unreviewed; 705 AA.
AC L9KMY6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Rho guanine nucleotide exchange factor 37 {ECO:0000313|EMBL:ELW64315.1};
GN ORFNames=TREES_T100010713 {ECO:0000313|EMBL:ELW64315.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW64315.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB320740; ELW64315.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KMY6; -.
DR STRING; 246437.L9KMY6; -.
DR eggNOG; KOG3519; Eukaryota.
DR InParanoid; L9KMY6; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd07589; BAR_DNMBP; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11799; SH3_ARHGEF37_C1; 1.
DR CDD; cd11941; SH3_ARHGEF37_C2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR035636; ARHGEF37_SH3_2.
DR InterPro; IPR035823; ARHGEF37_SH3_C1.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR22834; NUCLEAR FUSION PROTEIN FUS2; 1.
DR PANTHER; PTHR22834:SF9; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 37; 1.
DR Pfam; PF03114; BAR; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00721; BAR; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS51021; BAR; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 40..245
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 286..487
FT /note="BAR"
FT /evidence="ECO:0000259|PROSITE:PS51021"
FT DOMAIN 525..601
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 632..695
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 79777 MW; CE0A424A8933407D CRC64;
MVLSFPEPAV MADHRAEEPS SRSGSPDEEG RVSEDRSLLH QRLAVRELID TEISYLHTLQ
LCASDIRNHL QQLPQGDLDI LFSNIDDIIK VNSRFLHGLQ ETASKEEEQV YLIGNLFLEF
QEEFEHVYKV YCANYDQALL LVDAYRKEPA LQREIQRIIE AVVPHGLLTG ALEQECLVVD
LARPLAHHKS QSMSRGLVSL CERITKYPLL LQKILENTLP DAGAYPVLQR ATFALQDVNA
NINEYKIRKE VASKYSKVEQ LTLRERLARI NTHTLSKKTT RLSQLLKQEA GLVPKTEDKE
FDDLEERFQW VSVCVTELKN DLAAYLDNLE VFLRFRPHEC NLDIPGGPVV QYCNLARDLQ
LKAFLEFKQR LEALVWQPLC SLAKVLVGPQ NLIKKRLDKL LDFERVEEKL LEVGSVTYEE
EAARHTYQAL NSLLVAELPK FNQLVMQWLG QVLRTFVALQ RDLAEQVLQR AEGSMTQLPH
QHIPEPDFRK LVENSLGQTS KQLRSFRENF EKVLPPPTTQ PLLPGSERQV QALWSRYGPG
KLYQVTNNIS GAGSLDLTLP RGQIVALLQN KDTKGNSGRW LVDTGGHRGY VPAGKLQPYR
VVPSEEERRG QVGPHEDSRH LTPEPTPTCS VPTVTQVVAA YPFLARSSQE VSLQAGQPVT
LLEAQDKKGN PEWSLVEVNG QRGYVPSSFL ARAPSPAPWG WSLTS
//
