ID L9KNA1_TUPCH Unreviewed; 132 AA.
AC L9KNA1;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Fatty acid-binding protein, intestinal {ECO:0000256|ARBA:ARBA00020016};
DE AltName: Full=Fatty acid-binding protein 2 {ECO:0000256|ARBA:ARBA00030278};
DE AltName: Full=Intestinal-type fatty acid-binding protein {ECO:0000256|ARBA:ARBA00030558};
GN ORFNames=TREES_T100015054 {ECO:0000313|EMBL:ELW62617.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW62617.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- FUNCTION: FABPs are thought to play a role in the intracellular
CC transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is
CC probably involved in triglyceride-rich lipoprotein synthesis. Binds
CC saturated long-chain fatty acids with a high affinity, but binds with a
CC lower affinity to unsaturated long-chain fatty acids. FABP2 may also
CC help maintain energy homeostasis by functioning as a lipid sensor.
CC {ECO:0000256|ARBA:ARBA00034472}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding
CC protein (FABP) family. {ECO:0000256|ARBA:ARBA00008390,
CC ECO:0000256|RuleBase:RU003696}.
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DR EMBL; KB320806; ELW62617.1; -; Genomic_DNA.
DR RefSeq; XP_006153166.1; XM_006153104.2.
DR AlphaFoldDB; L9KNA1; -.
DR STRING; 246437.L9KNA1; -.
DR GeneID; 102467902; -.
DR KEGG; tup:102467902; -.
DR CTD; 2169; -.
DR eggNOG; KOG4015; Eukaryota.
DR InParanoid; L9KNA1; -.
DR OrthoDB; 2946847at2759; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005504; F:fatty acid binding; IEA:InterPro.
DR CDD; cd19445; FABP2; 1.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR031272; FABP2.
DR InterPro; IPR000463; Fatty_acid-bd.
DR InterPro; IPR031259; ILBP.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR PANTHER; PTHR11955; FATTY ACID BINDING PROTEIN; 1.
DR PANTHER; PTHR11955:SF89; FATTY ACID-BINDING PROTEIN, INTESTINAL; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PRINTS; PR00178; FATTYACIDBP.
DR SUPFAM; SSF50814; Lipocalins; 1.
DR PROSITE; PS00214; FABP; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003696}.
FT DOMAIN 5..22
FT /note="Cytosolic fatty-acid binding proteins"
FT /evidence="ECO:0000259|PROSITE:PS00214"
SQ SEQUENCE 132 AA; 15136 MW; 1023CD27838D006D CRC64;
MAFDGTWKID RNENYDKFME KMGINMVKRK LAAHDNLKLI ITQEGNKFTV KESSTFRNVD
IVFELGVTFN YSLADGTELT GTWNIEGNKL VGKFKRTDNG NELNAVREII GGELVQTYTY
EGVQAKRIFK KE
//
