ID L9KNH7_TUPCH Unreviewed; 446 AA.
AC L9KNH7;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Ribosome biogenesis protein WDR12 {ECO:0000256|HAMAP-Rule:MF_03029};
DE AltName: Full=WD repeat-containing protein 12 {ECO:0000256|HAMAP-Rule:MF_03029};
GN Name=WDR12 {ECO:0000256|HAMAP-Rule:MF_03029};
GN ORFNames=TREES_T100003074 {ECO:0000313|EMBL:ELW62712.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW62712.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- FUNCTION: Component of the PeBoW complex, which is required for
CC maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000256|HAMAP-Rule:MF_03029}.
CC -!- SUBUNIT: Component of the PeBoW complex, composed of BOP1, PES1 and
CC WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and
CC WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
CC {ECO:0000256|HAMAP-Rule:MF_03029}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000256|HAMAP-
CC Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000256|HAMAP-Rule:MF_03029}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC {ECO:0000256|HAMAP-Rule:MF_03029}.
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DR EMBL; KB320805; ELW62712.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KNH7; -.
DR STRING; 246437.L9KNH7; -.
DR InParanoid; L9KNH7; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR HAMAP; MF_03029; WDR12; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR028599; WDR12/Ytm1.
DR PANTHER; PTHR19855:SF11; RIBOSOME BIOGENESIS PROTEIN WDR12; 1.
DR PANTHER; PTHR19855; WD40 REPEAT PROTEIN 12, 37; 1.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|HAMAP-Rule:MF_03029};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517, ECO:0000256|HAMAP-
KW Rule:MF_03029};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552, ECO:0000256|HAMAP-
KW Rule:MF_03029};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 5..70
FT /note="NLE"
FT /evidence="ECO:0000259|Pfam:PF08154"
FT REPEAT 136..171
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 209..249
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 256..296
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 315..328
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 341..377
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 446 AA; 50188 MW; 99DC38EBDE4FE74C CRC64;
MAQLQTRFYT ENKKYAVEDV PFSIPATSEI ADLSNIINKL LQAKNEFHKH VEFDFLIKGQ
FLRMPLVKHM ELENISSEEV VELEYVEKYT APQPEQCMFH DDWISSIKGA EEWILTGSYD
KTSRIWSLEG KSIMTIVGHT DVVKDVAWVK KDNLSCLLLS ASMDQTILLW EWNVERNKVK
ALHCCRGHAG SVESIAVDSS GTKTPIVTLS GHKEAISSVL WSDTEEICSA SWDHTIRVWD
VESGSVKSTL TPIVTLSGHK EAISSVLWSD TEEICSASWD HTIRVWDVES GSVKSTLTGN
KVFNCISYSS LCKRLASGST DRHIRLWDPR TKDGSLVSLS LTSHTGWVTS VKWSPTHEQQ
LISGSLDNMV KLWDTRSCKA PLYDLAAHED KVLSVDWTDT GILTYHFPCR GMKVNDNLVL
EMCSVTEIGR ESLDYDDANV ESCLLD
//
