ID L9KP36_TUPCH Unreviewed; 881 AA.
AC L9KP36;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN ORFNames=TREES_T100001641 {ECO:0000313|EMBL:ELW62932.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW62932.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family. USP10 subfamily.
CC {ECO:0000256|ARBA:ARBA00005427}.
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DR EMBL; KB320797; ELW62932.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KP36; -.
DR STRING; 246437.L9KP36; -.
DR InParanoid; L9KP36; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR CDD; cd02257; Peptidase_C19; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR InterPro; IPR009818; Ataxin-2_C.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF687; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10; 1.
DR Pfam; PF07145; PAM2; 1.
DR Pfam; PF00443; UCH; 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 2.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:ELW62932.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 410..878
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 89..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 584..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 881 AA; 96443 MW; 3818F135C46025A1 CRC64;
MWYIFGDFSP DEFNQFFVTP RSSVELPPYS GTVLCGTQAA DELPDGQDYQ RIEFGVNEVT
EPSGTAPRLS YSISSTLNPQ APEFILGCTA PKKTPDGIDR DANHSSVDGQ YPDSALTLDG
SPSVEVDVLE NDGGSGGLGQ RERKKKKKRP PGYYSYLKDG SDSAIPTEAL VNGHTNSADP
SSVGTDDAEF VGDVPSSVTP RTCNSPQNST DFVRDTVPDG PFPGALDSVA RTAGQPGGCH
GTGFGHSCLP AEMGRGSLLR TAVAQPYVGT DTTENLGVAN GQILESSGEG TAANGVELHT
LESTDSDPRK AGSASPPADS AASAAGASPG SQPAKSWASL FHDSKPTSSS PVAYVETKYS
PPATSPLVSE KQAEVKEGPV PVSEDPVAIK IAELLENVTL IHKPVSLQPR GLINKGNWCY
INAEVPRARF FPLRFLTAHV QTLQALVACP PMYHLMKFIP LYSKVQRPCT STPMIDSFVR
LMNEFTNMPV PPKPRQGEYH VRLMNEFTNM PVPPKPRQAL GDKTVRDIRP GAAFEPTYIY
RLLTVIKSSL SEKGRQEDAE EYLGFILNGL HEEMLNLKKL LSPSNEKLPV SNGPKSHSVS
EEEQEEQGAG SEEEWEQVGP RNKSSVTRQA EFVQTPITGI FGGHIRSVVY QQSSKESATL
QPFFTLQLDI QSDKIRTVQD ALESLVARES VQGYTTKTKQ EVEISRRVTL EKLPPVLVLH
LKRFVYEKTG GCQKLIKNIE YPVDLEISKG NPVARFRVCE KCCFIIPKLD QVEISRRVTL
EKLPPVLVLH LKRFVYEKTG GCQKLIKNIE YPVDLEISKV VYHHGSSATG GHYTTDVFQI
GLNGWLRIDD QTVRAVSQHQ VVKPAAERAA YLLYYRRVNL L
//
