ID L9KR04_TUPCH Unreviewed; 167 AA.
AC L9KR04;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=Probable RNA-binding protein EIF1AD {ECO:0000256|ARBA:ARBA00020989};
DE AltName: Full=Eukaryotic translation initiation factor 1A domain-containing protein {ECO:0000256|ARBA:ARBA00031998};
GN ORFNames=TREES_T100019326 {ECO:0000313|EMBL:ELW65138.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW65138.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- FUNCTION: Plays a role into cellular response to oxidative stress.
CC Decreases cell proliferation. {ECO:0000256|ARBA:ARBA00025398}.
CC -!- SUBUNIT: Interacts with GAPDH and STAT1.
CC {ECO:0000256|ARBA:ARBA00011663}.
CC -!- SIMILARITY: Belongs to the EIF1AD family.
CC {ECO:0000256|ARBA:ARBA00007340}.
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DR EMBL; KB320702; ELW65138.1; -; Genomic_DNA.
DR RefSeq; XP_006149985.1; XM_006149923.2.
DR RefSeq; XP_006149986.1; XM_006149924.2.
DR RefSeq; XP_006149987.1; XM_006149925.1.
DR AlphaFoldDB; L9KR04; -.
DR STRING; 246437.L9KR04; -.
DR GeneID; 102500014; -.
DR KEGG; tup:102500014; -.
DR CTD; 84285; -.
DR eggNOG; KOG2925; Eukaryota.
DR InParanoid; L9KR04; -.
DR OrthoDB; 55184at2759; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd05792; S1_eIF1AD_like; 1.
DR Gene3D; 1.10.1200.180; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR039294; EIF1AD.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR InterPro; IPR001253; TIF_eIF-1A.
DR PANTHER; PTHR21641:SF0; RNA-BINDING PROTEIN EIF1AD-RELATED; 1.
DR PANTHER; PTHR21641; TRANSLATION INITIATION FACTOR-RELATED; 1.
DR Pfam; PF01176; eIF-1a; 1.
DR SMART; SM00652; eIF1a; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50832; S1_IF1_TYPE; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|PROSITE-ProRule:PRU00181};
KW Protein biosynthesis {ECO:0000256|PROSITE-ProRule:PRU00181};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 5..89
FT /note="S1-like"
FT /evidence="ECO:0000259|PROSITE:PS50832"
FT REGION 98..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 167 AA; 19300 MW; 5822013BE42E37A9 CRC64;
MSQATKRKHV VKEVLGEHMV PSDRQQIVRV LRTPGNNLHE VETAQGQRFL VSMPSKYRKN
IWIKRGDFLI VDPIEEGEKV KAEISFVLCK DHVRSLQKEG HWPEAFSEVA EKQNNRNRQT
QPELPAEPQD SSGEESSSED DSDLFVNTNR RQYHESEEDS EEEEEAS
//