ID L9KR10_TUPCH Unreviewed; 1094 AA.
AC L9KR10;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=ferroxidase {ECO:0000256|ARBA:ARBA00013107};
DE EC=1.16.3.1 {ECO:0000256|ARBA:ARBA00013107};
GN ORFNames=TREES_T100009825 {ECO:0000313|EMBL:ELW65143.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW65143.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O;
CC Xref=Rhea:RHEA:11148, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034; EC=1.16.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001830};
CC -!- SIMILARITY: Belongs to the multicopper oxidase family.
CC {ECO:0000256|ARBA:ARBA00010609}.
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DR EMBL; KB320701; ELW65143.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KR10; -.
DR STRING; 246437.L9KR10; -.
DR eggNOG; KOG1263; Eukaryota.
DR InParanoid; L9KR10; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
DR CDD; cd11021; CuRO_2_ceruloplasmin; 1.
DR CDD; cd04224; CuRO_3_ceruloplasmin; 1.
DR CDD; cd11022; CuRO_4_ceruloplasmin; 1.
DR CDD; cd04225; CuRO_5_ceruloplasmin; 1.
DR CDD; cd11012; CuRO_6_ceruloplasmin; 1.
DR Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 5.
DR InterPro; IPR048236; Ceruloplasmin-like_CuRO_5.
DR InterPro; IPR011707; Cu-oxidase-like_N.
DR InterPro; IPR011706; Cu-oxidase_C.
DR InterPro; IPR033138; Cu_oxidase_CS.
DR InterPro; IPR002355; Cu_oxidase_Cu_BS.
DR InterPro; IPR008972; Cupredoxin.
DR PANTHER; PTHR46806:SF7; COAGULATION FACTOR VIII; 1.
DR PANTHER; PTHR46806; F5/8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07731; Cu-oxidase_2; 2.
DR Pfam; PF07732; Cu-oxidase_3; 2.
DR SUPFAM; SSF49503; Cupredoxins; 6.
DR PROSITE; PS00079; MULTICOPPER_OXIDASE1; 3.
DR PROSITE; PS00080; MULTICOPPER_OXIDASE2; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00023065}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1094
FT /note="ferroxidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003999621"
FT DOMAIN 92..202
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07732"
FT DOMAIN 306..355
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07731"
FT DOMAIN 807..866
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07732"
FT DOMAIN 954..1059
FT /note="Plastocyanin-like"
FT /evidence="ECO:0000259|Pfam:PF07731"
SQ SEQUENCE 1094 AA; 125205 MW; 4E62D8474B097E25 CRC64;
MKILVLSIFL FLYWTPAWTK DKHYYIGIVE TTWNYAPNSG PKKLISVDTE NLDTYLQNGP
NRIGRTYKKA LYLQYTDEHF KTTVEKPDWL GFLGPIIKAE TGDKVYVHLK NYASRAYTFH
PHGVTYYKEH EGAIYPDNTV GAQKADDKVN PGEQYTYILD ISEEQSPGEG DSNCVTRIYH
SHIDAPKDIA SGLIGPLIIC KKDSLDKEKE KNVDQEFVVM FSVVDENLSW YLEDNIKTYC
SEPEKVDEDN EDFQESNRMY SVNGYAFGSL PGLSMCAGDQ VKWYLFGMGN EVDVHAAFFH
GQALTNKNYR IDTVNLFPAT LFEASMVAQN PGEWMLSCQN LNHLKAGLQA FFQVQDCKKP
PSEDNIPGRQ IRQYYIAAEE IIWNYAPSGI DTFTKENLTA PGSDSEVFFE QGATRIGGTY
KKLVYREYTD ASFTNKKKRG PEEEHLGLLG PVIWAQVGDI IRVTFHNKGD FPLSIVPTGV
SFNKKNEGTY YASRDSPLSG DVPPSASHVA PKETFTYEWT VPKEVGPTYA DPVCLAKMYY
SAVDPTKDIF TGLIGPMKIC KEGSLNADGR QKDVDKEFFL FPTVFDENES LLLDDNIRMF
TTAPDQVDKE DEDFQESNKM HSINGFMYGN QPGLNMCQGD SVVWYLFSAG NEADVHGIYF
TGNTYLSRGE RRDTVNLFPQ TSRTLLMQPD TKGTFDVECL TTDHYTGGMK QKYTVNQCRG
PSEQSTYYRG ERTYYIAAVE VEWDYSPTRK WEKELHHLQE RNVSNVFLDK EEFYIGSKYK
KVVYRQYTDG TFRVPVERRA EEEHLGILGP QLHADVGDKV KIIFKNMATR EYSIHAHGVK
TESSEVTPTL PGETHTYIWE IPERSGAGIE DSACIPWAYY STVDRVKDLY SGLIGPLIVC
RKHYMKIYNP IKKQEFSLLF LVFDENESWY LDDNIKTYSD HPEKVNKDNE EFIESNKMHA
INGRMFGNLQ GLTMHVGDEV NWYLMGMGNE IDLHTVHFHG HSFRYKHRGI YSSDVFEIFP
GTYQTLEMFP RTPGIWLLHC HVTDHIHAGM ETTYTVLPNE ASSQTHGKIW NVNYSFMISV
IILFQIPTKE WLGE
//
