ID L9KSM6_TUPCH Unreviewed; 880 AA.
AC L9KSM6;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Superkiller viralicidic activity 2-like 2 {ECO:0000313|EMBL:ELW65688.1};
GN ORFNames=TREES_T100005298 {ECO:0000313|EMBL:ELW65688.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW65688.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
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DR EMBL; KB320678; ELW65688.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KSM6; -.
DR STRING; 246437.L9KSM6; -.
DR eggNOG; KOG0948; Eukaryota.
DR InParanoid; L9KSM6; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd13154; KOW_Mtr4; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 2.40.30.300; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF7; EXOSOME RNA HELICASE MTR4; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 3.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 90..223
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 243..415
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 16..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..50
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..80
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 880 AA; 99903 MW; 2B4655476E980425 CRC64;
MADAFGDELF SVFEDDSTTA AGNKKDKEKE KGKLKGPPGS ADKAGKRFDS KLQSESTNSG
KNKRDTDFEG TDEPIFGKRP RIEESITEDL RYAIALALRE KQRVIFTSPI KALSNQKYRE
MYEEFQDVGL MTGDVTINPT ASCLVMTTEI LRSMLYRGSE VMREVAWVIF DEIHYMRDSE
RGVVWEETII LLPDNVHYVF LSATIPNARQ FAEWICHLHK QPCHVIYTDY RPTPLQHYIF
PAGGDGLHLV VDENGDFRED NFNTAMQVLR DAGDLAKGDQ KGRKGGTKDE EKKMVEEVFS
NAIDCLSDED KKLPQALFAT ETFAMGINMP ARTVLFTNAR KFDGKDFRWI SSGEYIQMSG
RAGRRGMDDR GIVILMVDEK MSPTVGKQLL KGSADPLNSA FHLTYNMVLN LLRVEEINPE
YMLEKSFYQF QHYRAIPGVV EKVKNSEEQY NKIVIPNEES VVIYYKIRQQ LAKLGKEIEE
YIHKPKYCLP FLQPGRLVKV KNEGDDFGWG VVVNFSKKSN VKPNSGELDP LYVVEVLLRC
SKESLKNSAT EAAKPAKPDE KGEMQVVPVL VHLLSAISSV RLYIPKDLRP VDNRQSVLKS
IQEVQKRFPD GVPLLDPIDD MGIQDQGLKK VIQKVEAFEH RMYSHPLHND PNLETVYTLC
EKKAQIAIDI KSAKRELKKA RTVLQMDELK CRKRVLRRLG FATSSDVIEM KGRVACEISS
ADELLLTEMM FNGLFNDLSA EQATALLSCF VFQENSSEMP KLTEQLAGPL RQMQECAKRI
AKVSAEAKLE IDEETYLSSF KPHLMDVVYT WATGATFAHI CKMTDVFEGS IIRCMRRLEE
LLRQMCQAAK AIGNTELENK FAEGITKIKR DIVFAASLYL
//
