ID L9KU13_TUPCH Unreviewed; 543 AA.
AC L9KU13;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Cholesteryl ester transfer protein {ECO:0000256|ARBA:ARBA00022354};
DE AltName: Full=Lipid transfer protein I {ECO:0000256|ARBA:ARBA00029686};
GN ORFNames=TREES_T100002931 {ECO:0000313|EMBL:ELW66188.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW66188.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2,3-tri-(9Z-octadecenoyl)-glycerol(in) = 1,2,3-tri-(9Z-
CC octadecenoyl)-glycerol(out); Xref=Rhea:RHEA:43352, ChEBI:CHEBI:53753;
CC Evidence={ECO:0000256|ARBA:ARBA00001417};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesteryl (9Z,12Z)-octadecadienoate(in) = cholesteryl
CC (9Z,12Z)-octadecadienoate(out); Xref=Rhea:RHEA:43356,
CC ChEBI:CHEBI:41509; Evidence={ECO:0000256|ARBA:ARBA00001140};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesteryl (9Z-octadecenoate)(in) = cholesteryl (9Z-
CC octadecenoate)(out); Xref=Rhea:RHEA:43348, ChEBI:CHEBI:46898;
CC Evidence={ECO:0000256|ARBA:ARBA00000222};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
CC {ECO:0000256|ARBA:ARBA00007292}.
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DR EMBL; KB320660; ELW66188.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KU13; -.
DR STRING; 246437.L9KU13; -.
DR InParanoid; L9KU13; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0034364; C:high-density lipoprotein particle; IEA:InterPro.
DR GO; GO:0120020; F:cholesterol transfer activity; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0043691; P:reverse cholesterol transport; IEA:InterPro.
DR CDD; cd00025; BPI1; 1.
DR InterPro; IPR017943; Bactericidal_perm-incr_a/b_dom.
DR InterPro; IPR017130; Cholesteryl_ester_transfer.
DR InterPro; IPR001124; Lipid-bd_serum_glycop_C.
DR InterPro; IPR017954; Lipid-bd_serum_glycop_CS.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR PANTHER; PTHR47616; CHOLESTERYL ESTER TRANSFER PROTEIN; 1.
DR PANTHER; PTHR47616:SF1; CHOLESTERYL ESTER TRANSFER PROTEIN; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
DR Pfam; PF02886; LBP_BPI_CETP_C; 1.
DR PIRSF; PIRSF037185; Cholesteryl_ester_transf; 2.
DR SMART; SM00328; BPI1; 1.
DR SMART; SM00329; BPI2; 1.
DR SUPFAM; SSF55394; Bactericidal permeability-increasing protein, BPI; 2.
DR PROSITE; PS00400; LBP_BPI_CETP; 1.
PE 3: Inferred from homology;
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037185-50};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..543
FT /note="Cholesteryl ester transfer protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003999737"
FT DOMAIN 31..282
FT /note="Lipid-binding serum glycoprotein N-terminal"
FT /evidence="ECO:0000259|SMART:SM00328"
FT DOMAIN 296..526
FT /note="Lipid-binding serum glycoprotein C-terminal"
FT /evidence="ECO:0000259|SMART:SM00329"
FT DISULFID 160..201
FT /evidence="ECO:0000256|PIRSR:PIRSR037185-50"
SQ SEQUENCE 543 AA; 59806 MW; D470AFE59C734514 CRC64;
MLATTLLTLA LLGSAHACSD GTSYEAGIVC RITKPALLVL NQETSKVIQT AFQRVNYPDI
KGEKAMMILG QVNYGLHNIQ ISHLSIASSQ VELVDATSID VSIQNVSVIF KGTLSYGYTG
AWGLSINQSV DFEIDSAIDL HIDTRLTCDS GSVRTNAPNC YLAFHKLRLH LQGEREPGWI
EQLFTNFISF TLKLVLKGQV CKEINVLSNI MADFVQRRAD GNPGAGGWGT CGQSLHLEAH
LPLSNILSDG DINVDISLTR SPVITATYLE SHHKGHFIYK NVSEDLALPT FSPSLLGDSR
MLYFWFSEHV LDSLAKAAFQ DGRLVLSLTG DKFKAVLETW GFHTNQDIFQ ELLMGLPPGQ
AQVTVHCLKK PTVSCQSKGV VVNSPVVVKF LFPRPGRQRV VAYTFEEDVI TTVQASYSKK
KLFLRLLDFQ YVLQRGEGVV GSESLSLATL VSGRTILALL GPGMDRSRSE SIQNLLQSII
TTVGIPEVMS RLEVVFTAFM NSKGLDLFEI IDPEIITQDG FLLLQMDFGF PEHLLVDFLQ
SLS
//
