ID L9KUJ3_TUPCH Unreviewed; 512 AA.
AC L9KUJ3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Aldehyde dehydrogenase, mitochondrial {ECO:0000256|ARBA:ARBA00040706};
DE EC=1.2.1.3 {ECO:0000256|ARBA:ARBA00024226};
DE AltName: Full=ALDH class 2 {ECO:0000256|ARBA:ARBA00041743};
DE AltName: Full=ALDH-E2 {ECO:0000256|ARBA:ARBA00042494};
GN ORFNames=TREES_T100016955 {ECO:0000313|EMBL:ELW66580.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW66580.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- FUNCTION: Required for clearance of cellular formaldehyde, a cytotoxic
CC and carcinogenic metabolite that induces DNA damage.
CC {ECO:0000256|ARBA:ARBA00037438}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH;
CC Xref=Rhea:RHEA:16185, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17478, ChEBI:CHEBI:29067, ChEBI:CHEBI:57540,
CC ChEBI:CHEBI:57945; EC=1.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024149};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix
CC {ECO:0000256|ARBA:ARBA00004305}.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
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DR EMBL; KB320648; ELW66580.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KUJ3; -.
DR STRING; 246437.L9KUJ3; -.
DR eggNOG; KOG2450; Eukaryota.
DR InParanoid; L9KUJ3; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd07141; ALDH_F1AB_F2_RALDH1; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699:SF233; ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Oxidoreductase {ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 40..503
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 280
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 512 AA; 55480 MW; 2D4C9570583A6147 CRC64;
MRPDVLAFTL PMALAPADGG SSTLTVAICE AALIFIDNEW HDAISKKTFP TVNPSTGEVI
CQVAAGDKED VDKAVKAARA AFQLGSPWRR MDASDRGRLL YRLADLIERD RTYLAALETL
DNGKPYVISY LVDLDMVLKC LRYYAGWADK YHGKTIPIDG DFFSYTRHEP VGVCGQIIPW
NFPLLMQAWK LGPALATGNV VVMKVAEQTP LTALYVANLI KEAGFPPGVV NIVPGFGPTA
GAAIASHDDV DKVAFTGSTE VGHLIQIAAG KSNLKRVTLE LGGKSPNIIM SDADMAWAVE
QAHFALFFNQ GQCCCAGSRT YVQEDVYAEF VERSVARAKS RVVGNPFDSQ TEQGPQVDET
QFKKILGYIQ SGKQEGAKLL CGGGPAADRG YFIQPTVFGD VQDGMTIAKE EIFGPVMQIL
KFKTIEEVVG RANNSKYGLA AAVFTKDLDK ANYLSQALQA GTVWVNCYDV FGAQSPFGGY
KMSGSGRELG EYGLQAYTEV KTVTVKVPQK NS
//
