ID L9KVS7_TUPCH Unreviewed; 1403 AA.
AC L9KVS7;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Gastric intrinsic factor {ECO:0000313|EMBL:ELW66921.1};
GN ORFNames=TREES_T100013881 {ECO:0000313|EMBL:ELW66921.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW66921.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the eukaryotic cobalamin transport proteins
CC family. {ECO:0000256|ARBA:ARBA00006449}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL16 family.
CC {ECO:0000256|ARBA:ARBA00008931}.
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DR EMBL; KB320635; ELW66921.1; -; Genomic_DNA.
DR eggNOG; ENOG502QT7B; Eukaryota.
DR InParanoid; L9KVS7; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0015934; C:large ribosomal subunit; IEA:UniProt.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0015889; P:cobalamin transport; IEA:InterPro.
DR GO; GO:0006824; P:cobalt ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd01433; Ribosomal_L16_L10e; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR Gene3D; 2.170.130.30; -; 2.
DR Gene3D; 3.90.1170.10; Ribosomal protein L10e/L16; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR002157; Cbl-bd_prot.
DR InterPro; IPR047873; Ribosomal_uL16.
DR InterPro; IPR016180; Ribosomal_uL16_dom.
DR InterPro; IPR036920; Ribosomal_uL16_sf.
DR InterPro; IPR027954; Transcobalamin-like_C.
DR PANTHER; PTHR10559:SF15; COBALAMIN BINDING INTRINSIC FACTOR; 1.
DR PANTHER; PTHR10559; TRANSCOBALAMIN-1/GASTRIC INTRINSIC FACTOR; 1.
DR Pfam; PF01122; Cobalamin_bind; 2.
DR Pfam; PF14478; DUF4430; 1.
DR Pfam; PF00252; Ribosomal_L16; 1.
DR SUPFAM; SSF54686; Ribosomal protein L16p/L10e; 1.
DR PROSITE; PS00468; COBALAMIN_BINDING; 2.
PE 3: Inferred from homology;
KW Cobalt {ECO:0000256|ARBA:ARBA00023285, ECO:0000256|PIRSR:PIRSR602157-1};
KW Cobalt transport {ECO:0000256|ARBA:ARBA00022426};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR602157-2};
KW Ion transport {ECO:0000256|ARBA:ARBA00022426};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transport {ECO:0000256|ARBA:ARBA00022426}.
FT DOMAIN 565..625
FT /note="Transcobalamin-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF14478"
FT REGION 993..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 768
FT /ligand="cyanocob(III)alamin"
FT /ligand_id="ChEBI:CHEBI:17439"
FT /evidence="ECO:0000256|PIRSR:PIRSR602157-1"
FT BINDING 819
FT /ligand="cyanocob(III)alamin"
FT /ligand_id="ChEBI:CHEBI:17439"
FT /evidence="ECO:0000256|PIRSR:PIRSR602157-1"
FT BINDING 867
FT /ligand="cyanocob(III)alamin"
FT /ligand_id="ChEBI:CHEBI:17439"
FT /evidence="ECO:0000256|PIRSR:PIRSR602157-1"
FT BINDING 966..967
FT /ligand="cyanocob(III)alamin"
FT /ligand_id="ChEBI:CHEBI:17439"
FT /evidence="ECO:0000256|PIRSR:PIRSR602157-1"
FT BINDING 992
FT /ligand="cyanocob(III)alamin"
FT /ligand_id="ChEBI:CHEBI:17439"
FT /evidence="ECO:0000256|PIRSR:PIRSR602157-1"
FT DISULFID 740..779
FT /evidence="ECO:0000256|PIRSR:PIRSR602157-2"
SQ SEQUENCE 1403 AA; 156174 MW; BF75F07CEF3E7EB2 CRC64;
MRHMLLCGTC QAEMLKQDLF PKSSDFTKTP DIRELSAWYE CPNNNRPLLT KEAQGHDRCG
SFSVLVECNR FNFRAIVKRA LFYTDELVGP DELFLGTGCQ AIHVRLDEME FDYPVTLCGI
ETQVLPGNWL LFESRITFMS VFAEFEASIL VFCAVPGHVA PIKINGYNAD KQSGPPRSSG
IANLPNGNAI NWELKKRLVE VQKKEDSRKC DLVHEKKTSS SNLAKENVKS LTLTCGQEVN
EENVFRLNPL LSTMINSKYI SGTQTANVLL SLKLVGVQNQ ALIQRLVQQL KDNVERKVSN
LSSGQLALII MALGACHTPD ETIIYDYHLI RHLENKFAVE IVHMETHNGN PLTNYYQLSL
DVLALCLFNG SYSTAKVAEY FTPKNKNYYF GGDFSVDTGA MAILALTCVK RNLVDGKIKT
DTEDLRSISN HIELLVKKIL SEKKKNGLIG NTFSTGEAMQ ALFVSSDYYQ ESDWDCQQTL
ETVLKKISQG AFSIPTAAAQ ILPALMGKTY LNVKNAYCAN VLGNFSVSTQ APVTVTPPNS
HSNILVHYSV RINKTYSINV TVPNGSVFLD VMEEAQKMNK TLYSFTMEES SWGPYITSVQ
GLRANSNDRT YWELLSGGKP LSQAAPSAQQ PLVNDIQVFM ENSVTSSSFP NPSILIAMNL
AGAYDVETQK LLTYKLMASD TSDLTIGQLA LTIMALTSSC RDPGNKVSIL QRQMENWAPP
SPNAEISAFY GPSLAILALC QKTSETVLPI AVRFAKTLLA NSSPFNVDTG AMATLALTCM
YNKIPVGSEE SYRVLFGQVL KDIVENISMR IKDNGIIGDI YSTGLAMQAL SVTPEKPNKE
WNCQKTMDTI LDEIKQGKFH NPMSIAQILP SLKGKTYLDV PQVICIPDHE VQPTLPNLPS
PVPTSASNIT VTYTINNQLR GIELLFNVTI NVSVKSGSVL LVVLEEAQRK NPMFKFEATM
TSWGLYISSI NNIAENVNHK TYWQFLSGKT PLNKESERRS AETQGERLHV ATPTAPRQPR
QAHRAPSNPT PEPKLRGSRC LDFRRNSLRK DPREHNFRSG SRLHSCGLSG FRGGSGPRVT
MWRLLARSGA QLLRVPVSGQ RCPLKKLPLF PQPPLNAVSP KPRKVRALVE ALVKGCYLSP
PPSPPPCKRS QLRLVVGAQR PRLAMLGTRA YSWAALPASA GLKTLLPVPA LDDVSIPEKP
KLRFVERVPL VPKVKREPKN LNDIRGPSTE ATEFTEGSFG ILALGGGYLR WGHFEMMRLT
INRSMDPKNM FAIWRIPAPY KPITRKGMGQ RMGGGKGAID HYVTPVKAGR LLVELGGRCE
FKEVQGFLDQ VAHKLPFRAK AVSRQTLEKM RKDQEERERN NQNPWTFERI ATANMLGIRK
VLSPYDLTQK GRYWGKFYMP ERV
//
