ID L9KVS9_TUPCH Unreviewed; 663 AA.
AC L9KVS9;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=Rabphilin-3A {ECO:0000313|EMBL:ELW66569.1};
GN ORFNames=TREES_T100016961 {ECO:0000313|EMBL:ELW66569.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW66569.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB320648; ELW66569.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KVS9; -.
DR STRING; 246437.L9KVS9; -.
DR InParanoid; L9KVS9; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd04035; C2A_Rabphilin_Doc2; 1.
DR CDD; cd08384; C2B_Rabphilin_Doc2; 1.
DR CDD; cd15762; FYVE_RP3A; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR028698; FYVE_RPH3A.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR043566; Rabphilin/DOC2/Noc2.
DR InterPro; IPR047022; Rabphilin_Doc2_C2A.
DR InterPro; IPR001565; Synaptotagmin.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45729; RABPHILIN, ISOFORM A; 1.
DR PANTHER; PTHR45729:SF3; RABPHILIN-3A; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02318; FYVE_2; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR PRINTS; PR00399; SYNAPTOTAGMN.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50916; RABBD; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 87..204
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT DOMAIN 135..192
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 380..502
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 519..652
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 68..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..360
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 663 AA; 74219 MW; 0F1649D526E99A04 CRC64;
MLLGVGSEAR AAQKTLCKEL TFWWKNSILK EITQFENQHM IHEQWPSTMT DTVFSSSNRW
TYPGDRPLQS KLQGGWSVHP NGQPDRQRKQ EELTDEEKEI INRVIARAEK MEAMEQERIG
RLVDRLENMR KNVAGDGVNR CILCGEQLGM LGSACVVCED CKKNVCTKCG VETSNNRPHS
VWLCKICIEQ REVWKRSGAW FFKGFPKQVL PQPMPIKKTK PQQPVSEPAA PEQPTPEPKQ
TARAPARGPD VASAPGRGSY GPPVRRASEA RMGSSGQESE SWDHGQSGAP GDSSRSPAEV
APSDPGYTGT TAPPREERTA GVGGYPAVGA REDRAGHPPG PYPQTPAAAP QPATAPARQP
PPPEEEEEEA NSYDSDEATT LGALEFSLLY DQDNSSLQCT IIKAKGLKPM DSNGLADPYV
KLHLLPGASK SNKLRTKTLR NTRNPVWNET LVYHGITDED MQRKTLRISV CDEDKFGHNE
FIGETRFSLK KLKPNQRKNF NICLERVIPQ VERIGDIEER GKILVSLMYS TQQGGLIVGI
IRCVHLAAMD ANGYSDPFVK LWLKPDMGKK AKHKTQIKKK TLNPEFNEEF FYDIKHSDLA
KKSLDISVWD YDIGKSNDYI GGCQLGISAK GERLKHWYEC LKNKDKKIER WHQLQNENHV
ASD
//
