ID L9KVU2_TUPCH Unreviewed; 332 AA.
AC L9KVU2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Suppressor of IKBKE 1 {ECO:0000256|ARBA:ARBA00041003};
DE AltName: Full=Suppressor of IKK-epsilon {ECO:0000256|ARBA:ARBA00042344};
GN ORFNames=TREES_T100005359 {ECO:0000313|EMBL:ELW65307.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW65307.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- FUNCTION: Physiological suppressor of IKK-epsilon and TBK1 that plays
CC an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-
CC mediated activation of interferon-stimulated response elements (ISRE)
CC and the IFN-beta promoter. May act by disrupting the interactions of
CC IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-
CC kappa-B activation pathways. {ECO:0000256|ARBA:ARBA00037749}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the SIKE family.
CC {ECO:0000256|ARBA:ARBA00005537}.
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DR EMBL; KB320698; ELW65307.1; -; Genomic_DNA.
DR AlphaFoldDB; L9KVU2; -.
DR STRING; 246437.L9KVU2; -.
DR eggNOG; ENOG502QTKS; Eukaryota.
DR InParanoid; L9KVU2; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 3.90.280.10; PEBP-like; 1.
DR InterPro; IPR036610; PEBP-like_sf.
DR InterPro; IPR008555; SIKE.
DR PANTHER; PTHR12186; SIKE FAMILY MEMBER; 1.
DR PANTHER; PTHR12186:SF4; SUPPRESSOR OF IKBKE 1; 1.
DR Pfam; PF05769; SIKE; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
SQ SEQUENCE 332 AA; 36867 MW; EF935DCB7C6533B2 CRC64;
MSCTIEKILT DAKTLLERLR EHDAAAESLV DQSAALHRRV AAMREAGTAL PDQYQEDASD
MKDMSKYKPH ILLSQENTQI RDLQQENREL WVSLEEHQDA LELIMSKYRK QMLQLMVAKK
AVDAEPVLKA HQSHSAEIES QIDRICEMGE VMRKAVQVDD DQFCKIQEKL AQLEGSALVG
VTQPLCASGL GVRAPPPVHA LGTRNSRERS EIYSYVPGRA AYGGAGEGAL SWGGEYDLGV
QFGVARSQAK GRLVLNFELF ESITRPSVLK LRTPLDPDMP VDLSKWFGPL SLPEVDERPQ
HPLQVTYAGA EVDELGKVLT PTQVKNRPTS IA
//
