ID L9KX58_TUPCH Unreviewed; 1786 AA.
AC L9KX58;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=Protein very KIND {ECO:0000313|EMBL:ELW67303.1};
GN ORFNames=TREES_T100016921 {ECO:0000313|EMBL:ELW67303.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW67303.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
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DR EMBL; KB320619; ELW67303.1; -; Genomic_DNA.
DR STRING; 246437.L9KX58; -.
DR eggNOG; ENOG502QSHW; Eukaryota.
DR InParanoid; L9KX58; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011019; KIND_dom.
DR InterPro; IPR029899; KNDC1.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR21560:SF0; KINASE NON-CATALYTIC C-LOBE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR21560; VERY KIND PROTEIN; 1.
DR Pfam; PF16474; KIND; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00750; KIND; 2.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS51377; KIND; 2.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 37..217
FT /note="KIND"
FT /evidence="ECO:0000259|PROSITE:PS51377"
FT DOMAIN 458..622
FT /note="KIND"
FT /evidence="ECO:0000259|PROSITE:PS51377"
FT DOMAIN 1279..1408
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1505..1756
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 215..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 986..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..839
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..874
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..907
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1033..1049
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1786 AA; 195896 MW; 9ACF440D396206D2 CRC64;
MQAMDPAAAD FYEEDGKDLD FYDFEPLPTL AEDEENVSLA DILSLRDSGL SEQEAWAVCL
ECSLSMRSVA HAAIFQTLCI TPDTLAFNTS GNVCFMEQLS DDPEGAFVPP EFDVTGNTFE
AHIYSLGATL KAALEYVAEP ELEPRLSQDL EALLSQMQAE DPGDRPSLES IIALCEEKMQ
LTSSCRLCRS LSAVGRRVLS IESFGAFQDV SENTWRGRPA PRSVGPKRSL GDLSPDPEAL
PAPGGLPQPP ASEGPERETD RGSRSLLSKS LLSGPVKNGE SHSRDGLPSL ILDNRCPLGE
LDRDFLKRSR LRKVQTFPRL LPEGPEANGL CLSLTSTKSQ LPVSEFFPAD PRKVLPEGKN
GLFSIKAPST RRLWPEQESK PQPMEPPGTG HGDDRGPGVP GDLGPPETAA HPDQAPAEER
PCPCPMDPGD ADQVTQTPED DKTEEAGQPG STATEQWVSL QDLLSKLGRP FREYELWALC
LACLRALQMH AKHPAYLCLD SVLVAEDGVV LFGPPPVNGS YNSFFLAPEV AEEKLVTEKA
SVYCVAAVLW TAAKFSIPHG HKLALPRRLK TLLLDMAKRS APERPSAAEA IKVCSSYLLQ
RGMDSRKILA HLRASTCKVY QEEETISLQN AFSVVELKPL GAPSPEPSPG FMPVTNDTRL
VAMPGPMPGQ SSCNEGTTEL PVAFTSEATH FKPIVLTQDA GVDREQLALP SEQAEGPEES
SGRLDRDSEG KHVPQAHTGV TSPMTTKGPV PAPEPHGADP EALRESVPCG LAQGCSCPPP
SSPVHQPEGA SLATPGSPAP TLPPKALVLP LKPGLDGQVP PEAPSMGLGP CPPGPTSDNH
GLPRPSKPPR SKVTECPGQK PEGPQSTTRG PSLAAVSPDS PRGTPVRERG DHTPESHSER
PRPADRKLCP SGVDASSLQD AMRLIQEEFA FDGYLDNGLE ALIMGEYIFA LKDLTFATFC
GAISEKFCDL YWDEKLLQNL FKVVNGPTSP SESISEESMS QPENTPSSCS PSSKRPSLHR
LGKEKPAMAR TSRGPCSPTS LSDMDSDELS QGNFEVGFRP QKSVKSTREQ QPTAGEDEQQ
GGGPEPASGA SDVDIVARLA RPDESSPVIS PGPAEFRSCS PGWSSAFYEA DCFGTEVHNY
VKDLGRQKAS GSPEPDAQSP ELEQQLMIEK RNYRKTLKFY QKLLQKEKRN KGSEVKTMLS
KLKGQLEEMK SKVQFLGLVK KYLQVMYAER WGLEPCALPV IVNIAAAHCD TLDFSPLDES
SSLIFYNVNK HPCGSRQKKA RILQAGTPLG LMAYLYSSPT CSDAFLEGYV QQFLYTFRYF
CTPHDFLHFL LDRINSTLSR AHQDPTSTFT KIYKRSLCVL QAWVEDCYTV DFTRNTGLLG
QLEDFISSKI LPLDGSAEHL LGLLEVGTDR RAEGTPRGTD LEDPKEAEEE ARPFNALCKR
LSEDGISRKS FPWRLPRGNG LTLPHHKERQ YTIASALPKP CFFEDFYGPY AKASEKGPYF
LTEYSTHQLF SQLTLLQQEL FQKCHPVHFL NSRALGVMDK SAAIPKTSSS ESLSAKTCSL
FLPNYVQDKY LLQLLRNADD VSNWVAAEIV TSHTSKLQVN LLSKFLLIAK SCYEQRNFAT
AMQILGGLEH LAVRQSPAWR ILPAKIAEVM EELKAVEVFL KSDSLCLMEG RRFRAQPTLP
SARLLAMHIQ QLETGGFTMT NGAHRWSKLR NIAKVVSQVH AFQENPYTFS PDPKLQSYLK
QRIARFSGAD ISILAADNRA NFHQMSSEKH SRKIQDKLRR MKATFQ
//
