ID   L9KXF6_TUPCH            Unreviewed;       734 AA.
AC   L9KXF6;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   SubName: Full=FCH domain only protein 1 {ECO:0000313|EMBL:ELW67169.1};
GN   ORFNames=TREES_T100014665 {ECO:0000313|EMBL:ELW67169.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW67169.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23385571; DOI=10.1038/ncomms2416;
RA   Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA   Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA   Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA   Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA   Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT   "Genome of the Chinese tree shrew.";
RL   Nat. Commun. 4:1426-1426(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
CC       {ECO:0000256|ARBA:ARBA00004283}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004283}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004283}.
CC   -!- SIMILARITY: Belongs to the FCHO family.
CC       {ECO:0000256|ARBA:ARBA00011064}.
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DR   EMBL; KB320623; ELW67169.1; -; Genomic_DNA.
DR   AlphaFoldDB; L9KXF6; -.
DR   STRING; 246437.L9KXF6; -.
DR   eggNOG; KOG2398; Eukaryota.
DR   InParanoid; L9KXF6; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR028565; MHD.
DR   InterPro; IPR018808; Muniscin_C.
DR   PANTHER; PTHR23065:SF6; F-BAR DOMAIN ONLY PROTEIN 1; 1.
DR   PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF10291; muHD; 1.
DR   SMART; SM00055; FCH; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   PROSITE; PS51072; MHD; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT   DOMAIN          496..734
FT                   /note="MHD"
FT                   /evidence="ECO:0000259|PROSITE:PS51072"
FT   REGION          1..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          349..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          423..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..48
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..484
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   734 AA;  79533 MW;  BE0AABC0630631A7 CRC64;
     MCDLGRAPLQ PGPEIHQPEI WGPVPQTGLF FDPSSSPPPP PPPASLVPKP EQGEKNHGFE
     VLYHSVKQGP ISTKELADFI RERATIEETY SKAMAKLSKL ASNGTPMGTF APLWEVFRVS
     SDKLALCHLE LTRKLQDLIK DVLRYGEEQL KTHKKCKDEV VGTLDAVQVL TGVSQLLPKS
     RENYLNRRFQ AMEETHLRHM KALLGSYAHS VEDTHVQIGQ VHEEFKQNIE NVSVEMLIRK
     FAESKGTGQE KPSPLDFEAY SAAVLQEGND VLEPDSGTCP EVDEEGFTVR PDVTQNNILL
     APPPGSCCDS DFDDEEPRKF YVHIKPPPAR APACSSEAAA AQLRATAGSL ILPPGPGGTM
     KRHSSRDAAG KPQRPRSAPR AGSCAEKLLS DEQVSKNLFG PPLESAFDHE DFTDLIPAAA
     DSAAREGLAA PPRRPRTRKV SCPLTRSNGD LSRSLSPSPL GTSAPSAVPE RPSFSSQTSH
     GVSRGPSPVV LGSQDALPVA TAFTEYVHAY FRGHNTSCLA RVTGELTMTF PAGIVRVFSG
     TPPPPVLSFR LIHTAPIEHF QPNADLVFSD PSQSDPEAKD FWLNMATLTE ALQQQAEQNP
     AASYYNVVLL KYQFSRPGPQ SVPLQLSAHW QCGATLTQVS VEYSYRPGAT AVPTPLTNVQ
     ILLPVGEPVT NVRLQPAATC WEPLSGPSTP SPVAAQFTSE GATLSGVDVE LVGGGYRMSL
     VKRRFATGMY LVSC
//