ID   L9L0B5_TUPCH            Unreviewed;       872 AA.
AC   L9L0B5;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Leucine-rich repeat-containing protein 45 {ECO:0000313|EMBL:ELW68189.1};
GN   ORFNames=TREES_T100007358 {ECO:0000313|EMBL:ELW68189.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW68189.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23385571; DOI=10.1038/ncomms2416;
RA   Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA   Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA   Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA   Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA   Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT   "Genome of the Chinese tree shrew.";
RL   Nat. Commun. 4:1426-1426(2013).
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DR   EMBL; KB320577; ELW68189.1; -; Genomic_DNA.
DR   AlphaFoldDB; L9L0B5; -.
DR   STRING; 246437.L9L0B5; -.
DR   eggNOG; KOG4308; Eukaryota.
DR   InParanoid; L9L0B5; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd01871; Rac1_like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR23170:SF3; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 45; 1.
DR   PANTHER; PTHR23170; NY-REN-58 ANTIGEN; 1.
DR   Pfam; PF13516; LRR_6; 3.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00368; LRR_RI; 4.
DR   SMART; SM00175; RAB; 1.
DR   SMART; SM00173; RAS; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS51419; RAB; 1.
DR   PROSITE; PS51421; RAS; 1.
DR   PROSITE; PS51420; RHO; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT   COILED          323..442
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          469..663
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   872 AA;  98061 MW;  370C4E9A73E4C8CE CRC64;
     MEEFRRSYSR LCRESGAEPQ EAVLQQLHQL PMGRLDLATH SLTVDTCRAL GSLLRNEALL
     TELVLSDCML SEDGAALLLH GLCANSVLRL LDLKGNNLRA VGAEALGKLL RQNRAIQSLT
     LEWNSLGTWE EAFATFCGGL AANSTLQQLD LRNNQISHKG AEALALALKG NAALQQLDLR
     WNNVGLLGGR ALVSSLPSSR TLWRLELAGN NVPGDILRAV EAEDPRPGTD SMEPALAIRA
     CAVYLRRGQA RAPPIPEQAM DHNQNRRTAF QEAQARTRVL SKEFLDLMET IDKQREEMAR
     TGRATAARVM RLQEALDERG SIVNALQAKL QMTEAALALS EQKAEDLGER LALAQQEQQS
     LLQRQAQEHR LEQQEAAERE AKLLRDLAAA HEKNLLLRNQ VDELERRARS QQEQLFLTRQ
     ELAELRMRAV QAEERLDVEK RRSKQSLEGA ENLRSKEVEH MTRHLEESER AMQERVQRLE
     AVRLSLEEEL SRVKAAALSE RGQAEEELMK AKNQARLEEQ QRLAHLEDKL RRLAQARDEA
     QDACLQQKQT VAEAQARASQ LGLQVEALRR RLEELQQELS NKDQERVAEV ARVRVELQEQ
     NGRLQAELAA QEALKEKAAA LERQMKVIAS DHREALLDRE SENASLREKL RLKEAEIARV
     REEEVQRASV LQNAVLAYVQ GSPLRALSPQ NAVGKTCLLI SYTTNAFPGE YIPTVFDNYS
     ANVMVDGKPV NLGLWDTAGQ EDDDRLRPLS YPQTDVFLIC FSLVSPASFE NTCAPQWYPE
     VRHHCPHTPI LLVGTKLDLR DDKDTLERLR DKKLAPITYP QGLAMAREIG SVKYLECSAL
     TQRGLKTVFD EAIRAVLCPP PVKKPGKRCT VF
//