ID L9L0X3_TUPCH Unreviewed; 1600 AA.
AC L9L0X3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Pleckstrin homology domain-containing family G member 5 {ECO:0000313|EMBL:ELW68701.1};
GN ORFNames=TREES_T100008905 {ECO:0000313|EMBL:ELW68701.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW68701.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR EMBL; KB320563; ELW68701.1; -; Genomic_DNA.
DR STRING; 246437.L9L0X3; -.
DR eggNOG; KOG3521; Eukaryota.
DR InParanoid; L9L0X3; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13244; PH_PLEKHG5_G6; 1.
DR CDD; cd17068; RBD_PLEKHG5; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd13420; TNFRSF25; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR040181; PKHG5/7.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022329; TNFR_25.
DR InterPro; IPR034050; TNFRSF25_N.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR13217:SF11; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5; 1.
DR PANTHER; PTHR13217; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR01972; TNFACTORR25.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00208; TNFR; 2.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1399..1422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 436..611
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 707..807
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REPEAT 1315..1358
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 1315..1358
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT DOMAIN 1529..1596
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 121..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 886..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 951..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1230..1249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 828..844
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..871
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..977
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1600 AA; 176929 MW; B3CBB88028BF85B6 CRC64;
MFLYWRKRGA YELEALPGDL AELELGAVER FSWSSTLDII EDLGDDQSQA EEKGLLCQNP
ACMDKGRAAK VCHHTDCQQL HRRGPLNLCE ACDSKFHNTM HYDGHVRFDL PPQGSVLARN
VSTRSCPPRT CPAVDLEEEE EDSSMDSKGD RKSTGLKLSK KKARRRHTDD PSKECFTLKF
DLNVDIETEI VPAMKKKSLG EVLLPVFERK GIALGKVDIY LDQSNTPLSL TFEAYRFGGH
YLRVKAKPGD EGKVEQGVKD SKSLSLPILR PSGAGLPILE RVDPQSRRES LDILAPGRRR
KNMSEFLGEA SIPGQDPPLA SSSSLPSGSS GSTSSGREEP GSQSFQWLLQ LGSQHQRLWP
GLFQEVDKME QLEGKLHAYS LFGLPRLPRR LRFDHDSWEE EEEEEEEDDN STCLRLEDSW
RELIDGHEKL TRRQCHQQEA VWELLHTEAS YIRKLRVITN VEAERLFSNI PEIARLHRGL
WGSVMAPVLE KARRTRVLLQ PGDFLKGFKM FGSLFKPYIR YCMEEEGCME YMRSLLRDNE
LFRAYVTWAE KHQQCQRLKL SDMLAKPHQR LTKYPLLLKS ILRKTDEPHA KEAVITMINS
VERFIHHVNA CMRQRQERQR LGAGGGTSQH FSVTYPQINS VERFIHHVKP CVRQRQERQR
LAAVVSRIDA YEVVEGSTDE VDKLLKEFLH LDLTAPIPGA SPEETRQLLL EGSLRMKEGK
DSKMDVYCFL FTDLLLVTKA VKKAERTKVI RPPLLVDKIV CRELRDPGSF LLIYLNEFHS
AVGAYTFQAS GQALCRGWVD AIYNAQNQLQ QLRVQEHPGS QQHLQSLEEE EEEQEEEEEE
EGEGSSTSAA SSPTILRKSS NSLNSQHCAS DGSTETLAMV VVEPGETLSS PDFDGGPFSS
QSDKTSLSTT ASSITPTSEL LPLGPVDGRS CSMDSAYGTL SPTSLQDFVG PAPVMEPMPG
PPELPQVSSP PPSPRLRRRT PVQLLPRLPH LLKSKSEASL LQLLSGDSTR GALSGPSRSL
SELCLAATAS GARTRGSPQG GGPGWDCHGA LSPGNGPELS ERQERANSLA GEPAGPTSRR
CRELPSGASS RAQLEPPPGT SAQHRKLTLA QLYRIRTTLL LNSTLTASTQ NNPSLDPYLG
LNWWISGLEL DLGCGQDATL SICPSWQQAT QSVQPTLDEA AALMWCPTLL TPVKGPSATW
RAMEPQPGGC RVAVAAQPEK RAELRANAGV SEVEEPGQGD PHSAQPGWKS AASAPQALLL
VLLGAQGQGS SPSPGCDCAS DGQKKYGQFC CRGCPAGFYL QAPCTKPCGA SICLPCPQGT
FLAKENHHKT RCARCQACDE QASQVALENC SAVADTDCGC EPGWFVECLV SQCIDSSPFE
CLPCLDCGAL HRHTQRPLFW VQVLLAGLAV PLLLGATLTY AYRRCRPPKP RVPDKARREI
LISPQATHSP PSNSVHTVLM PASSSEKVCT VQLVGNSWMP SSPQTQETPY SPAMCSWEPM
PSRALGSLTA VLQPGPQLYD VVDAVPVRRW KEFVRTLGLR EAEIEAVEVE ISRFRDQQYE
MLKRWRQQQP AGLGAVYAAL ERMGLDGCAE DLRSRLQRGP
//
