ID L9L1J8_TUPCH Unreviewed; 652 AA.
AC L9L1J8;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Poly [ADP-ribose] polymerase 12 {ECO:0000313|EMBL:ELW68838.1};
GN ORFNames=TREES_T100005105 {ECO:0000313|EMBL:ELW68838.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW68838.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SIMILARITY: Belongs to the ARTD/PARP family.
CC {ECO:0000256|ARBA:ARBA00024347}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB320557; ELW68838.1; -; Genomic_DNA.
DR AlphaFoldDB; L9L1J8; -.
DR STRING; 246437.L9L1J8; -.
DR eggNOG; ENOG502QSC4; Eukaryota.
DR InParanoid; L9L1J8; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:InterPro.
DR CDD; cd01439; TCCD_inducible_PARP_like; 1.
DR Gene3D; 3.30.1370.210; -; 1.
DR Gene3D; 3.30.720.50; -; 1.
DR Gene3D; 3.90.228.10; -; 1.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR InterPro; IPR004170; WWE-dom.
DR InterPro; IPR037197; WWE_dom_sf.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR45740; POLY [ADP-RIBOSE] POLYMERASE; 1.
DR PANTHER; PTHR45740:SF6; PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP12; 1.
DR Pfam; PF00644; PARP; 1.
DR Pfam; PF02825; WWE; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR SMART; SM00356; ZnF_C3H1; 2.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF117839; WWE domain; 1.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
DR PROSITE; PS50918; WWE; 2.
DR PROSITE; PS50103; ZF_C3H1; 2.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00723};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00723}.
FT DOMAIN 117..139
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 209..236
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 224..300
FT /note="WWE"
FT /evidence="ECO:0000259|PROSITE:PS50918"
FT DOMAIN 303..409
FT /note="WWE"
FT /evidence="ECO:0000259|PROSITE:PS50918"
FT DOMAIN 435..649
FT /note="PARP catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51059"
FT ZN_FING 117..139
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 209..236
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 73115 MW; 2A332F80EC48A6DE CRC64;
MPVALSCSSR PLPQPRRTEP RWGEGSAPLA LPSVSPAPSA VSAWPVSVGC HGLVTDTATS
PGSDEACGAT RGSRHVVCVG GAREVGWMPR AVCLHYNKGD GPYGSCSFRK QCIKLHICQY
FLQGECKFGT SCKRSHSFSN SENLEKLEKL GMSSDLVSRL PSIYRNAYDI KNKSSAPIPA
HPTPLGPQGT SERRGSCSGP VSPNTPSQEE NDQICLYHIR KSCSFQDKCN RVHFHLPYRW
QFFDGGKWKD LDKMELIEEA YCNPKKHRVL CSELGSSFHS DCLNFDSMMF GTSRARRLST
ASSVTKPPHF ILTTDWVWYW MDEYDSWQEY GKQEVSKYEN IDLYQDAMHP TTTISSGDVE
KAYLVWCIPG SDASAASLKF EAGKHKYELD FKAFVQKNLV YGTVRKVCRR PKYVSPQDVK
TKQICGVKFQ GPKSIPDYWD PSALPDPGFK KIALSSSSAE YQKVSTLFHL TLPYYHIQKV
ERVQNLALWE VYQWQKGQMQ KQNGGKEVDE RQLFHGTSAS FVDAICQQNF DWRVCGLHGT
SYGKGSYFAR DAAYSHHYSK SDTQSHTMFL ARVLVGEFVR GSSSFVRPPA KVGQSNTFYD
SCVNSMSDPS IFVIFEKHQV YPEYLIQYSS SAHPQAGTSL LMALGSLFSG RQ
//
