ID L9L253_TUPCH Unreviewed; 777 AA.
AC L9L253;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Beta-2-glycoprotein 1 {ECO:0000256|ARBA:ARBA00020104};
DE AltName: Full=Apolipoprotein H {ECO:0000256|ARBA:ARBA00029855};
DE AltName: Full=Beta-2-glycoprotein I {ECO:0000256|ARBA:ARBA00033414};
GN ORFNames=TREES_T100002787 {ECO:0000313|EMBL:ELW67467.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW67467.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- FUNCTION: Binds to various kinds of negatively charged substances such
CC as heparin, phospholipids, and dextran sulfate. May prevent activation
CC of the intrinsic blood coagulation cascade by binding to phospholipids
CC on the surface of damaged cells. {ECO:0000256|ARBA:ARBA00003651}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; KB320609; ELW67467.1; -; Genomic_DNA.
DR AlphaFoldDB; L9L253; -.
DR STRING; 246437.L9L253; -.
DR eggNOG; KOG4297; Eukaryota.
DR InParanoid; L9L253; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 4.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 5.
DR InterPro; IPR027831; DUF4485.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR015104; Sushi_2.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR18871; CENTROSOMAL PROTEIN OF 112 KDA; 1.
DR PANTHER; PTHR18871:SF2; CENTROSOMAL PROTEIN OF 112 KDA; 1.
DR Pfam; PF14846; DUF4485; 1.
DR Pfam; PF00084; Sushi; 4.
DR Pfam; PF09014; Sushi_2; 1.
DR SMART; SM00032; CCP; 4.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 5.
DR PROSITE; PS50923; SUSHI; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..777
FT /note="Beta-2-glycoprotein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004000385"
FT DOMAIN 21..81
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 82..139
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 140..202
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 203..262
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 754..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 411..505
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 539..570
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 756..771
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 23..66
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 110..137
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 205..248
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 777 AA; 89844 MW; 896BE6EEC2DBF124 CRC64;
MIFPAFILFS SFLCHVAIGG RTCPKPDDLP FSIVVPLKTS YDPGEQIVYS CKPGYVSRGG
MRRFTCPLTG MWPINTLKCI PRVCPFAGIL ENGVVRYTTF EYPNSISFSC NTGFYLNGAS
SVKCTEEGKW SEELPVCTPI TCPPPQVPKF AMLSVHKSSA GNDSLYHDTV VFKCLPHYAM
FGNDTITCTA HGNWTELPEC REVKCPFPSR PDNGFVNYPA HQALYYKDKA TYGCHDTYTL
DGPEEVECSK LGNWSAQPSC KASCRLSVKK ATVLYQGERV KLQEQFKNGM KHGDKVSFFC
KNKEKKCSYT EDAVCVDGTI EIPKCFKERQ RCALWIRKLC EPSGTGTGIT GRKNRNLYAK
LLLHMLKRGV LEGPFTHRPE PGTLKILPSY MLHNAVAEME KEKFDLQKRH TENIQELLED
TNVRLNKMES EYMAQTQSTN HVVKELEARV QQLTGEAENS NLQRQKLIQE KMELERCYQI
TCSELQEVKA RRNTLHKEKD HLINDYEQNM KLLQTKYDAD INLLKQEHAL SASKASGMIE
ELEQNICQLK QQLQESELQR KQQLRDQENK FQMEKSLVKH TLSINQPCHW QIHDLQSELD
KEKEDAKKRI HKFEEALKEK EEQLTRVTEV QRLQAQQADA ALEEFKRQVE LNSEKVYAEM
KEQMEKVEAD LTRSKSLREK QSKDFLWQLE DVKQRYEKQI VELKLEHEQE KTHLLQQHNA
EKDSLVRDHE REIENLERQL RAANMEHENQ IQEFKKRDAQ NNNNNNNNKA ALRAVIL
//