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Database: UniProt
Entry: L9L253_TUPCH
LinkDB: L9L253_TUPCH
Original site: L9L253_TUPCH 
ID   L9L253_TUPCH            Unreviewed;       777 AA.
AC   L9L253;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=Beta-2-glycoprotein 1 {ECO:0000256|ARBA:ARBA00020104};
DE   AltName: Full=Apolipoprotein H {ECO:0000256|ARBA:ARBA00029855};
DE   AltName: Full=Beta-2-glycoprotein I {ECO:0000256|ARBA:ARBA00033414};
GN   ORFNames=TREES_T100002787 {ECO:0000313|EMBL:ELW67467.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW67467.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23385571; DOI=10.1038/ncomms2416;
RA   Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA   Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA   Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA   Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA   Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT   "Genome of the Chinese tree shrew.";
RL   Nat. Commun. 4:1426-1426(2013).
CC   -!- FUNCTION: Binds to various kinds of negatively charged substances such
CC       as heparin, phospholipids, and dextran sulfate. May prevent activation
CC       of the intrinsic blood coagulation cascade by binding to phospholipids
CC       on the surface of damaged cells. {ECO:0000256|ARBA:ARBA00003651}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR   EMBL; KB320609; ELW67467.1; -; Genomic_DNA.
DR   AlphaFoldDB; L9L253; -.
DR   STRING; 246437.L9L253; -.
DR   eggNOG; KOG4297; Eukaryota.
DR   InParanoid; L9L253; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR   CDD; cd00033; CCP; 4.
DR   Gene3D; 2.10.70.10; Complement Module, domain 1; 5.
DR   InterPro; IPR027831; DUF4485.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR015104; Sushi_2.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   PANTHER; PTHR18871; CENTROSOMAL PROTEIN OF 112 KDA; 1.
DR   PANTHER; PTHR18871:SF2; CENTROSOMAL PROTEIN OF 112 KDA; 1.
DR   Pfam; PF14846; DUF4485; 1.
DR   Pfam; PF00084; Sushi; 4.
DR   Pfam; PF09014; Sushi_2; 1.
DR   SMART; SM00032; CCP; 4.
DR   SUPFAM; SSF57535; Complement control module/SCR domain; 5.
DR   PROSITE; PS50923; SUSHI; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00302}; Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..777
FT                   /note="Beta-2-glycoprotein 1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004000385"
FT   DOMAIN          21..81
FT                   /note="Sushi"
FT                   /evidence="ECO:0000259|PROSITE:PS50923"
FT   DOMAIN          82..139
FT                   /note="Sushi"
FT                   /evidence="ECO:0000259|PROSITE:PS50923"
FT   DOMAIN          140..202
FT                   /note="Sushi"
FT                   /evidence="ECO:0000259|PROSITE:PS50923"
FT   DOMAIN          203..262
FT                   /note="Sushi"
FT                   /evidence="ECO:0000259|PROSITE:PS50923"
FT   REGION          754..777
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          411..505
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          539..570
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        756..771
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        23..66
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT   DISULFID        110..137
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT   DISULFID        205..248
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ   SEQUENCE   777 AA;  89844 MW;  896BE6EEC2DBF124 CRC64;
     MIFPAFILFS SFLCHVAIGG RTCPKPDDLP FSIVVPLKTS YDPGEQIVYS CKPGYVSRGG
     MRRFTCPLTG MWPINTLKCI PRVCPFAGIL ENGVVRYTTF EYPNSISFSC NTGFYLNGAS
     SVKCTEEGKW SEELPVCTPI TCPPPQVPKF AMLSVHKSSA GNDSLYHDTV VFKCLPHYAM
     FGNDTITCTA HGNWTELPEC REVKCPFPSR PDNGFVNYPA HQALYYKDKA TYGCHDTYTL
     DGPEEVECSK LGNWSAQPSC KASCRLSVKK ATVLYQGERV KLQEQFKNGM KHGDKVSFFC
     KNKEKKCSYT EDAVCVDGTI EIPKCFKERQ RCALWIRKLC EPSGTGTGIT GRKNRNLYAK
     LLLHMLKRGV LEGPFTHRPE PGTLKILPSY MLHNAVAEME KEKFDLQKRH TENIQELLED
     TNVRLNKMES EYMAQTQSTN HVVKELEARV QQLTGEAENS NLQRQKLIQE KMELERCYQI
     TCSELQEVKA RRNTLHKEKD HLINDYEQNM KLLQTKYDAD INLLKQEHAL SASKASGMIE
     ELEQNICQLK QQLQESELQR KQQLRDQENK FQMEKSLVKH TLSINQPCHW QIHDLQSELD
     KEKEDAKKRI HKFEEALKEK EEQLTRVTEV QRLQAQQADA ALEEFKRQVE LNSEKVYAEM
     KEQMEKVEAD LTRSKSLREK QSKDFLWQLE DVKQRYEKQI VELKLEHEQE KTHLLQQHNA
     EKDSLVRDHE REIENLERQL RAANMEHENQ IQEFKKRDAQ NNNNNNNNKA ALRAVIL
//
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