ID L9L5K4_TUPCH Unreviewed; 838 AA.
AC L9L5K4;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Transcriptional repressor NF-X1 {ECO:0000313|EMBL:ELW70258.1};
GN ORFNames=TREES_T100010615 {ECO:0000313|EMBL:ELW70258.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW70258.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NFX1 family.
CC {ECO:0000256|ARBA:ARBA00007269}.
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DR EMBL; KB320502; ELW70258.1; -; Genomic_DNA.
DR AlphaFoldDB; L9L5K4; -.
DR STRING; 246437.L9L5K4; -.
DR InParanoid; L9L5K4; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06008; NF-X1-zinc-finger; 2.
DR CDD; cd02643; R3H_NF-X1; 1.
DR CDD; cd16696; RING-CH-C4HC3_NFX1; 1.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR034078; NFX1_fam.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR034076; R3H_NF-X1.
DR InterPro; IPR000967; Znf_NFX1.
DR PANTHER; PTHR12360; NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1; 1.
DR PANTHER; PTHR12360:SF12; TRANSCRIPTIONAL REPRESSOR NF-X1; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF01422; zf-NF-X1; 4.
DR SMART; SM00393; R3H; 1.
DR SMART; SM00438; ZnF_NFX; 4.
DR SUPFAM; SSF82708; R3H domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51061; R3H; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 712..780
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT REGION 25..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 838 AA; 94388 MW; 3DC51B101A57F104 CRC64;
MSISFVLGTF KFNTDAAEFV PQERKNSGLN CGTQRRLDSS KTGRRNYNSP PPCHVSRQVP
YDDIFPVHQH SYPSGNKPKS QQNSFQSSAS NKSPKNHGLQ NQLWQKSKSE KQHIRVKKVQ
GVTEQNSDTT DIESVLRSEN GTNPREHSPS ESEKEVVSAD PRGAKPKKTT QFIYNHGRGP
KVKGKLRCEW SGKVTPKPED ARPENTKPVG ISHPDSLDAS IRKGVLDGYG ARRNEQRRYP
QKRPPWEVEG ARPRPGRNPP KQESQRHMNT GPKNNMVPVL KDKLSERPAK SACDSGNLAV
VSKSSRRADQ EKCTVRRQDP HVVSPFPRGK QNHVLKNVET HTGSLIEQLT TEKYECMVCC
ELVRVTAPVW SCQSCYHVFH LNCIKKWARS PASQAGKVKN PEWSRNEIPH SCGEVCRKKQ
PGQDCPHSCN LLCHPGPCPP CPAFMTKTCE CGRTRHTVRC GQAISVHCSS PCENVLNCGQ
HHCAELCHAG ECQPCRIILN QDATFMCDKR CNKKRLCGRH KCNEICCVDK EHKCPLICGR
KLRCGLHRCE EPCHRGNCQT CWQASFDELT CHCGASVIYP PVPCGTRPPE CTQTCARIHE
CDHPELQCEC GRRKEMVICS EASSTYQRIA AISMASKITD MQLGDTVEIS KLITKKEVHQ
ARLECDEECS ALERKKRLAE AFDISDDSDP FNIRSSGSKF SDSLKDEARK DLKFVSDIEK
EMETLVEAVN KGKNSKKSHC FPPMNRDHRR LIHDLAQVYG LESVSYDSEP KRNVVITAVR
GRSICPPTTL TVVLEREMQT RPPPPIPHHR HQTDRSPGSS NLQKITKEPI IDYFDVQD
//
