ID L9L5W2_TUPCH Unreviewed; 798 AA.
AC L9L5W2;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=TREES_T100005113 {ECO:0000313|EMBL:ELW68822.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW68822.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR EMBL; KB320557; ELW68822.1; -; Genomic_DNA.
DR AlphaFoldDB; L9L5W2; -.
DR STRING; 246437.L9L5W2; -.
DR eggNOG; KOG2189; Eukaryota.
DR InParanoid; L9L5W2; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF26; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 4; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 2.
DR PIRSF; PIRSF001293; ATP6V0A1; 2.
PE 3: Inferred from homology;
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 361..385
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 405..424
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 503..524
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 530..554
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 600..619
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 729..754
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT REGION 633..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 798 AA; 91027 MW; A5F7400A019B69D2 CRC64;
MASVFRSEEM CLSQLFLQVE AAYCCVAELG ELGLVQFKDL NVNVNSFQRK FVNEVRRCES
LERILRFLED EMKNEVVIQF PEKYPATPLP REMITLETET NLADDFFTED TSGLLELRTV
PAYMTGKLGF TAGVINRERM ASFERLLWRV CRGNIYLKFS EMDTPLEDPV TKEELKKNIF
IIFYQGEQLR KKIEKICDGF RATIYPCPEA AAERREMLAG VNVRLEDLIT VITQTDSHRQ
HLLQEAAANW HSWVIKVQKM KAIYHILNMC NIDVTQQCVI AEIWFPVADT GRIKRALEQG
VELSGSSMVP IMTTVQPKTD PPTFNRTNKF TAGFQNIVDA YGVGSYREIN PAPYTIITFP
FLFAVMFGDC GHGIVMFLAA LWMVLNEKNL LAQKSTNEIW NTFFHGRYLI LLMGIFSIYT
GLIYNDCFSK SLNIFGSSWS VQPMFRNGTW NTQVMQTNTL LQLDPAMPGV YSGNPYPFGI
DPIWNLASNK LTFLNSYKMK MSVILGIVQM VFGVILSLFN HVHFRKPLNI ILQFIPEMIF
ILCLFGYLVF MIIFKWCQFD VHVSQHAPSI LIHFINMFMF NYNDPSNAPL YKHQQEVQSF
FVVMALISVP WMLLIKPFIL RANHRKSQLQ SSMAQIDARE DTEGDNSSPS TSSGQKTSAG
VHGAEDDHEG EFNFGDVFVH QAIHTIEYCL GCISNTASYL RLWALSLAHA QLSEVLWTMV
MNMGLSLRGW AGLIGVFIIF AVFAVLTVAI LLIMEGLSAF LHALRLHWVE FQNKFYAGAG
YKFSPFSFKS ILEGTSEE
//
