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Database: UniProt
Entry: L9L7K7_TUPCH
LinkDB: L9L7K7_TUPCH
Original site: L9L7K7_TUPCH 
ID   L9L7K7_TUPCH            Unreviewed;       313 AA.
AC   L9L7K7;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=Apolipoprotein E {ECO:0000256|ARBA:ARBA00019891};
GN   ORFNames=TREES_T100011509 {ECO:0000313|EMBL:ELW71090.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW71090.1, ECO:0000313|Proteomes:UP000011518};
RN   [1] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000011518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23385571; DOI=10.1038/ncomms2416;
RA   Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA   Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA   Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA   Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA   Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT   "Genome of the Chinese tree shrew.";
RL   Nat. Commun. 4:1426-1426(2013).
CC   -!- SUBCELLULAR LOCATION: Endosome, multivesicular body
CC       {ECO:0000256|ARBA:ARBA00004559}. Extracellular vesicle
CC       {ECO:0000256|ARBA:ARBA00034305}. Secreted, extracellular space
CC       {ECO:0000256|ARBA:ARBA00004239}. Vesicle
CC       {ECO:0000256|ARBA:ARBA00004373}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC       {ECO:0000256|ARBA:ARBA00008788}.
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DR   EMBL; KB320473; ELW71090.1; -; Genomic_DNA.
DR   RefSeq; XP_006142127.1; XM_006142065.2.
DR   RefSeq; XP_014438467.1; XM_014582981.1.
DR   AlphaFoldDB; L9L7K7; -.
DR   STRING; 246437.L9L7K7; -.
DR   GeneID; 102477939; -.
DR   CTD; 348; -.
DR   eggNOG; ENOG502QVD6; Eukaryota.
DR   InParanoid; L9L7K7; -.
DR   OrthoDB; 4591103at2759; -.
DR   Proteomes; UP000011518; Unassembled WGS sequence.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   Gene3D; 1.20.120.20; Apolipoprotein; 2.
DR   InterPro; IPR000074; ApoA_E.
DR   PANTHER; PTHR18976; APOLIPOPROTEIN; 1.
DR   PANTHER; PTHR18976:SF2; APOLIPOPROTEIN E; 1.
DR   Pfam; PF01442; Apolipoprotein; 1.
DR   SUPFAM; SSF58113; Apolipoprotein A-I; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Chylomicron {ECO:0000256|ARBA:ARBA00022513};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   HDL {ECO:0000256|ARBA:ARBA00022850};
KW   Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW   Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Lipoprotein {ECO:0000313|EMBL:ELW71090.1};
KW   Oxidation {ECO:0000256|ARBA:ARBA00023097};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW   Transport {ECO:0000256|ARBA:ARBA00022448};
KW   VLDL {ECO:0000256|ARBA:ARBA00023313}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..313
FT                   /note="Apolipoprotein E"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004000106"
FT   COILED          236..274
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   313 AA;  35886 MW;  F371CAC3501F06C9 CRC64;
     MKVLWAVLAF AFLTGCRADV EPQLEPEVRE PPKWQAGQPW ELALGRFWDY LRWVQTLSDQ
     VQEELLSSQV TQELTVLMEE TMKEVKAYKA ELEEQLGPMK EETQARLSKE LQAAQARLGA
     DMEDVRTRLA QYRSEVQTML GQSTEELRAR LSSHLRKMRK RLLRDAEDLQ KRLAVYRAGV
     QEGAERGVSA IRERLGPLME QGRLRANTVS ALAAQPLQER AQAWGERLRG RLQEVGSQAR
     DRLDEVREQV EEVRAKVEEQ ATQMRLQAEA FQARLQSWFE PLVKDVQRQW AELVEKVQAA
     VGTSAAPVSS ENH
//
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