ID L9L9S7_TUPCH Unreviewed; 972 AA.
AC L9L9S7;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Presequence protease, mitochondrial {ECO:0000256|ARBA:ARBA00020167};
DE AltName: Full=Pitrilysin metalloproteinase 1 {ECO:0000256|ARBA:ARBA00032857};
GN ORFNames=TREES_T100002461 {ECO:0000313|EMBL:ELW71643.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW71643.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- SUBUNIT: Monomer and homodimer; homodimerization is induced by binding
CC of the substrate. {ECO:0000256|ARBA:ARBA00011853}.
CC -!- SIMILARITY: Belongs to the peptidase M16 family. PreP subfamily.
CC {ECO:0000256|ARBA:ARBA00007575}.
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DR EMBL; KB320457; ELW71643.1; -; Genomic_DNA.
DR AlphaFoldDB; L9L9S7; -.
DR STRING; 246437.L9L9S7; -.
DR MEROPS; M16.009; -.
DR InParanoid; L9L9S7; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 6.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR013578; Peptidase_M16C_assoc.
DR PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR Pfam; PF08367; M16C_assoc; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR SMART; SM01264; M16C_associated; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:ELW71643.1};
KW Protease {ECO:0000313|EMBL:ELW71643.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 462..644
FT /note="Peptidase M16C associated"
FT /evidence="ECO:0000259|SMART:SM01264"
FT REGION 699..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 972 AA; 109814 MW; A7B3360C14034E77 CRC64;
MWRSPRPGPG TVTSVPELFL TAVKLSHDNT GARYLHLARD DTNNLFSVQF RTTPLDSTGV
PHILEHTVLC GSKKYPCRDP FFKMLNRSLS TFMNAFTASD YTLYPFSTQN HKDFQNLLSV
YLDATFFPCL RELDFWQEGW RLEHENPSDP NTPFIFKGVV FNEMKGAFVN NERIFSQHLQ
NRLLPDHTYS VISGGDPLCI PELTWEQLKQ FHATHYHPSN ARFFTYGNFP LEKHLRQIDE
EALCKFQKIE PNTTVPAQKP WDKPREFQIT CGPDSFAADP AKQTTVSVSF LLPDITDTFE
AFTLSLLSSL LISGPNSPFY KALIESGLGT DFSPDVGYNG YTREAYFSVG LQGIAEKDIQ
TVRNLVDQTI DEVAEKGFED DRIEALLHKI EIQMKHQSTS FGLTLTSYIA SCWNHDGDPV
ELLKLGNQLT KFRQCLKENP TFLQEKVKQY FKNNQHKLTL SMKPDDKYHE KQAQMETEKL
KQKVNSLSLE DKQQIYEKGL ELRSQQSKPH DASCLPALKV SDIEPTIPHT ELAVALAAGE
TPVQYCAQPT NGMVYFRAFS SLNTLPEELR PYVPLFCSVL TNPCFEEEEH FKVLVKMTAQ
ELSNGIPDSG HLYASIRASR TLTPAGDLQE TFSGMDQVRL MKRIAEMTDI RPVLRKFPRI
KKHLLNCDNM RCSVNATPQQ MSQTEKAVEN FIRNVGRSKK ERRPVRPHVV EKPVQSGSGG
NAHINGSPII RKLITDPTFT PCQMKTHFLL PFPVNYVGEC VRTVPYTDPD HASLKILARL
MTAKFLHTEI REKGGAYGGG AKLSHSGIFT FYSYRDPNSI ETLQSFAKAV DWAKSGKFTQ
QDIDEAKLSV FSAVDAPVAP SDKGMDHFLY GLSDEMKQVH REQLFAVSHD KLTAVSNKYL
GVGKSTHGMD HFLYGLSDEM KQVHREQLFA VSHDKLTAVS NKYLGVGKST HGLALLGPEN
AKIAKDPSWI IK
//
