ID L9L9T3_TUPCH Unreviewed; 1932 AA.
AC L9L9T3;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Rho guanine nucleotide exchange factor 17 {ECO:0000313|EMBL:ELW71860.1};
GN ORFNames=TREES_T100008492 {ECO:0000313|EMBL:ELW71860.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW71860.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
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DR EMBL; KB320452; ELW71860.1; -; Genomic_DNA.
DR STRING; 246437.L9L9T3; -.
DR eggNOG; KOG3522; Eukaryota.
DR InParanoid; L9L9T3; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF15; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011518}.
FT DOMAIN 934..1122
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..786
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1431..1454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1486..1585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1857..1889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1905..1924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..663
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1507..1555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1870..1885
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1908..1922
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1932 AA; 207084 MW; 277FB6CDE61ABA8B CRC64;
MEVVGRGGQG GLGEPERQRA QESWTLQSQA RVGEAQGGAW RTGAAETAGQ AGARASCSSS
SSNASSYPVS HRQAASSSEE EEEGPLPSPG APRPAFHGGH SSGSDEDQVG EGGHRQGGRP
RLRPGSSLLD QDCRLDSDGL NLGSMDSSGG ARSPEPPTSP RVPSEEGPRE LGTGSPPCVP
GPQEGLRPVS DTVGGAFRVA KVSFPAYLAS PAGSRGSSRY SSTETLKDED LWSSRSGGWG
MYRSPSFGAG EGLLRPQSRT RAKGPVGATR ALRDGGLEPD KSRQRKSLSN PDIASETLTL
LSFLRSDLSE LRVRKPGGSP GDPGSSPLDG RDSPSAGGPM GKLGPMPAPA PASPGIRPTL
KDLTATLRRA KSFTCSEKPV PRRLARASAL KPSSSELLLA GPGAEEDPLP LVVQDQYVQE
ARQVFEKIQR MGAQQEDGND VPPGSPDWAG HLTCGQRSQE ELSGPESSLT DEGIGADPEP
PVAAFCGLST TGVWRPLSLS SAQTNHHGPG TEDSLGGWTL VSPETPPTPG ALRRRRKVPP
SGLGGIELSN GEAGEAYRSL SDPIPQRHRA ATSEEPSGFS VDSNLLGSLS PKSGLPATPA
MDEGLTSGHS DWSVGSEESK GYQEVIQSIV QGPGALRRVE DDRAAGKAPK KKSLSDPSRR
GELADSGFEG PGGEPIREVE PMLPPSSSEP ILAEQRPEPE EPSPARGRAQ SERVLPEAPP
ASAARRDFHL DPKLANVLSP RLIRRGSKKR PARSSHQELR REEGSQDQAG SPSGARPSSK
HVRHASVPAT FMPIVVPEPP ASMGPPVTVP EPMGFPARGH PTLQAPSLED VTKQYMLTLR
SGEVPVPGPV DMPCLTSVAP PSTEAKRPEA ARAPDEPTPA SKCCKPQVMV KTLAQFTIAL
EDMRDLGPAA ASGEPTRGSG TGTDTEEPGE TQDMRKHVTM TLLDTEQSYV ESLRTLMQGY
MQPLKQPENS LLCDPSLVDE IFDQIPELLE HHEQFLEQVR HCVQTWHAQQ KVGALLVQSF
SKDVLVNIYS AYIDNFLNAK DAVRVAKEAR PAFLKFLEQS MRENKEKQAL SDLMIKPVQR
IPRYELLVKD LLKHTPEDHP DHPLLLDAQR NIKQVAERIN KGVRSAEEAE RHARVLQEIE
AHIEGMEDLQ APLRRFLRQE MVIEVKAIGG KKDRSLFLFT DLIVCTTLKR KSGSLRRSSM
SLYTAASVID TASKYKMLWK LPLEDADIIK GASQATNREN IQKAISRLDE DLTTLSQMSK
LSESLGFPHQ SLDDALRDLS AAMHRDLSEK QALCYALSFP PTKLELCATR PEGTDSFIFE
FPHPDARLGF EQAFDEAKRK LASSKSCLDP EFLKAIPIMK TRSGMQFSCA APTLSSCPEP
TPEVWVCNSD GYVGQVCLLS LRAEPDVEAC IAVCSARILC IGAVPGLQRR SHRERPSSLR
RAPETAPDPS GSELDVEAAA DEEAATLAES GPQPCLHISI AGSGLEMAPG PVEGDPRPEL
VPFDSDSDDE SSPSPSGTLQ SQASRSTISS SFGNEETPSS KEATAETTSS EEEQEPGFLA
LSGSFGPGGP CGSSPMDGRA LRRSSRGSFT RGSLEDLLSV DPEAYQSSVW LGTEDGCVHV
YQSSDSIRDR RNSLKLQHAA SVTCILYLNN QVFVSLANGE LMVYQREAGR FWDPQNFKSV
TLGAQGSPIT KMVSVGGRLW CGCQNRVLVL SPDTLQLEHT FYVGQDSSRS VACMVDSSLG
VWVTLKGSAH VCLYHPDTFE QLAEVDVTPP VHRMLAGSDA IIRQHKAACL RITALLVCEE
LLWVGTSAGV VLTMPTSPST VSCPRAPLSP AGLGQGHTGH VRFLAAVQLP DGFNLLCPTP
PPPPDTGPEK LPSLEHRDSP RHRSLASAKP KMLVISGGDG YEDFRLSSGG SGGSSETVGR
DDSTNHLLLW RV
//
