ID L9LCD0_TUPCH Unreviewed; 533 AA.
AC L9LCD0;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=5'-3' exonuclease PLD3 {ECO:0000256|ARBA:ARBA00039647};
DE EC=3.1.16.1 {ECO:0000256|ARBA:ARBA00039059};
DE AltName: Full=Choline phosphatase 3 {ECO:0000256|ARBA:ARBA00042227};
DE AltName: Full=Phosphatidylcholine-hydrolyzing phospholipase D3 {ECO:0000256|ARBA:ARBA00043136};
DE AltName: Full=Phospholipase D3 {ECO:0000256|ARBA:ARBA00041681};
GN ORFNames=TREES_T100020220 {ECO:0000313|EMBL:ELW72354.1};
OS Tupaia chinensis (Chinese tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW72354.1, ECO:0000313|Proteomes:UP000011518};
RN [1] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Zhang G., Fan Y., Yao Y., Huang Z.;
RT "Genome of the Chinese tree shrew, a rising model animal genetically
RT related to primates.";
RL Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011518}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23385571; DOI=10.1038/ncomms2416;
RA Fan Y., Huang Z.Y., Cao C.C., Chen C.S., Chen Y.X., Fan D.D., He J.,
RA Hou H.L., Hu L., Hu X.T., Jiang X.T., Lai R., Lang Y.S., Liang B.,
RA Liao S.G., Mu D., Ma Y.Y., Niu Y.Y., Sun X.Q., Xia J.Q., Xiao J.,
RA Xiong Z.Q., Xu L., Yang L., Zhang Y., Zhao W., Zhao X.D., Zheng Y.T.,
RA Zhou J.M., Zhu Y.B., Zhang G.J., Wang J., Yao Y.G.;
RT "Genome of the Chinese tree shrew.";
RL Nat. Commun. 4:1426-1426(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 5'- to 3'-direction to yield
CC nucleoside 3'-phosphates.; EC=3.1.16.1;
CC Evidence={ECO:0000256|ARBA:ARBA00035759};
CC -!- SUBUNIT: Interacts with APP. {ECO:0000256|ARBA:ARBA00038809}.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00037858}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00037858}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004639}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004639}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00037797}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00037797}. Lysosome lumen
CC {ECO:0000256|ARBA:ARBA00004227}.
CC -!- SIMILARITY: Belongs to the phospholipase D family.
CC {ECO:0000256|ARBA:ARBA00008664}.
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DR EMBL; KB320423; ELW72354.1; -; Genomic_DNA.
DR AlphaFoldDB; L9LCD0; -.
DR STRING; 246437.L9LCD0; -.
DR eggNOG; KOG3603; Eukaryota.
DR InParanoid; L9LCD0; -.
DR Proteomes; UP000011518; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR CDD; cd09144; PLDc_vPLD3_1; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR032803; PLDc_3.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR PANTHER; PTHR10185:SF16; 5'-3' EXONUCLEASE PLD3; 1.
DR PANTHER; PTHR10185; PHOSPHOLIPASE D - RELATED; 1.
DR Pfam; PF00614; PLDc; 1.
DR Pfam; PF13918; PLDc_3; 2.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000011518};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..60
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 194..221
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 454..480
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
SQ SEQUENCE 533 AA; 59404 MW; BF6060C9F625E9CE CRC64;
MKPKLMYQEL KVPAEDSASE LPMNEIEAWK AAEKKARWVL LVLILAVVGF GALMTQLFLW
EYGDLHLFGP NQRPAPCYDP CEAVLVESIP EGLDFPNAST GNPSTSQAWL GLLAGAHSSL
DIASFYWTLT NNDTHTQEPS AQQGEEVLRQ LQTLAPKGVK VRIAVSKPNG PQPDLQALLQ
SGAQVRMVDM QKLTHGVLHT KFWVVDQTHF YLGSANMDWR SLSQTQYRLL QVKELGVVMY
NCSCLARDLT KIFEAYWFLG QAGSSIPSTW PRPYDTRYNQ ETPMEICLNG TPALAYLASA
PPPLCPSGRT PDLKALLNVV DNARSFIYIA VMNYMPTMEF SHPHSGRTPD LKALLNVVDN
ARSFIYIAVM NYMPTMEFSH PHSFGPAIDD GLRRAAYERG VKVRLLVSCW GHSEPSMRAF
LLSLAALRDN HTHSDIQVKL FVVPADEGQA RIPYARVNHN KYMVTERATY IGTSNWSGNY
FTETAGTSLL VTQNGRGGLR SQLEAVFLRD WDSPYSHDLD ASADSVGNAC RLL
//
