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Database: UniProt
Entry: L9LCY9_TUPCH
LinkDB: L9LCY9_TUPCH
Original site: L9LCY9_TUPCH 
ID   L9LCY9_TUPCH            Unreviewed;      2231 AA.
AC   L9LCY9;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   16-JAN-2019, entry version 21.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 2 {ECO:0000313|EMBL:ELW72534.1};
DE   Flags: Fragment;
GN   ORFNames=TREES_T100009630 {ECO:0000313|EMBL:ELW72534.1};
OS   Tupaia chinensis (Chinese tree shrew).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX   NCBI_TaxID=246437 {ECO:0000313|EMBL:ELW72534.1};
RN   [1] {ECO:0000313|EMBL:ELW72534.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zhang G., Fan Y., Yao Y., Huang Z.;
RT   "Genome of the Chinese tree shrew, a rising model animal genetically
RT   related to primates.";
RL   Nat. Commun. 0:0-0(2013).
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DR   EMBL; KB320405; ELW72534.1; -; Genomic_DNA.
DR   InParanoid; L9LCY9; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:ELW72534.1};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2193   2215       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       81    135       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      142    192       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      200    256       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      263    341       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      347    403       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       58     78       {ECO:0000256|SAM:Coils}.
FT   COILED     1564   1584       {ECO:0000256|SAM:Coils}.
FT   COILED     1890   1910       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ELW72534.1}.
SQ   SEQUENCE   2231 AA;  254716 MW;  B9018D2BE12EA229 CRC64;
     LVDDRCVVHP EAGDLANPPK KFRDCLFKVC PMNRYSAQKQ YWKAKQAKQG NHTEAALLKK
     LQHAAELEQK QNESENKKLL GEIVKYSNVI QLLHIKSNKY LTVNKRLPAL LEKNAMRVSL
     DAAGNEGSWF YIHPFWKLRS EGDNIVVGDK VVLMPVNAGQ PLHASNIELL DNPGCKEVNA
     VNCNTSWKIT LFMKYSSYRE DVLKGGDVVR LFHAEQEKFL TCDEYEKKQH IFLRTTLRQS
     ATSATSSKAL WEIEVVHHDP CRGGAGQWNS LFRFKHLATG NYLAAELNPD YRDAQNEGKN
     VRDGDLPTSK KKRQAGEKIM YTLVSVPHGN DIASLFELDA TTLQRADCLV PRNSYVRLRH
     LCTNTWVTST SIPIDTDEER PVMLKIGTCQ TKEDKEAFAI VSVPLSEVRD LDFANDANKV
     LATTVKKLEN GTITQNERRF VTKLLEDLIF FVADVPNNGQ EVLDVVITKP NRERQKLMRE
     QNILAQVFGI LKAPFKEKAG EGPMLRLEDL GDQRYAPYKY MLRLCYRVLR HSQQDYRKNQ
     EYIAKNFCVM QSQIGYDILA EDTITALLHN NRKLLEKHIT AKEIETFVSL LRRNREPRFL
     DYLSDLCVSN TTAIPVTQEL ICKFMLSPGN ADILIQTKVV SMQADNPLES SLLPDDIDDE
     EVWLYWIDSN KEPHGKAIRH LAQEAKEGTR ADLEVLTYYR YQLNLFARMC LDRQYLAINQ
     ISTQLSVDLI LRCMSDESLP FDLRASFCRL MLHMHVDRDP QESVVPVRYA RLWTEIPTKI
     TIHEYDSITD SSRNDMKRKF ALTMEFVEEY LKEVVNQPFP FGDKEKNKLT FEVVHLARNL
     IYFGFYSFSE LLRLTRTLLA ILDIVQAPMS SYFERLSKFQ DGGNNVMRTI HGVGEMMTQM
     VLSRGSIFPM SVPDVQPSIH PSKQGSPTEH EDVTVMDTKL KIIEILQFIL SVRLDYRISY
     MLSIYKKEFG ENSENAESAG GPPDTLLPSA IVPDIDEIAA QAETMFAGRK EKNPVQLDDE
     GGRTFLRVLI HLIMHDYPPL LSGALQLLFK HFSQRAEVLQ AFKQVQLLVS NQDVDNYKQI
     KADLDQLRLT VEKSELWVEK SSSYENGEMS ENQVKGGEEP IEESNILSPV QDGTKKPQID
     SNKSNNYRIV KEILIRLSKL CVQNKKCRSQ HQRLLKNMGA HSVVLDLLQI PYEKNDEKMN
     EVMNLAHTFL QNFCRGNPQN QALLHKHLNL FLTPGLLEAE TMRHIFMNNY HLCNEISERV
     VQHFVHCIET HGRHVEYLRF LQTIIKADGK YVKKCQDMVM TELINGGEDV LIFYNDRASF
     PILLHMMCSE RDRGDESGPL AYHITLVELL AACTEGKNFY TEIKCNSLLP LDDIVRVVTH
     DDCIPEVKIA YVNFVNHCYV DTEVEMKEIY TSNHIWKLFE NFLVDMARVC NTTTDRKHAD
     IFLERCVTES IMSIVSGFFN SPFSDNSTSL QTHQPVFIQL LQSAFRIYNC TWPNPAQKAS
     VESCIRTLAE VAKNRGIAIP VDLDSQVNTL FMKSHSNMVQ RAAMGWRLSA RSGPRFKEAL
     GGPAWDYRNI IEKLQDVVAS LEQQFSPMMQ AEFSVLVDVL YSPELLFPEG SDARIRCGAF
     MSKLINHTKK LMEKEEKLCI KILQTLREML EKRDSFMEEG NTLRKILLNR YFKGEYGSGM
     NGHLSGSYSK TAQGGGGFSG QDSDKTGTSM SDIQCLLDKE GASELVIDVI VNTKNDRIFS
     EGILLGIALL EGGNTQTQYS SYQQLHEQKK SEKFFKVLYD RMKAAQKEIR STVTVNTTDL
     GSKKRDDDNE VMPSGPRMRV RDSPLHLKEG MKGQLTEASS ATSKAYCVYR REMDPEIDIM
     CTGPEVGNAE DKSAEEVTMS PVIAIMQPIL RFLQLLCENH NRELQNFLRN QNNKTNYNLV
     CETLQFLDCI CGSTTGGLGL LGLYINEKNV ALVNQTLESL TEYCQGPCHE NQTCIATHES
     NGIDIIIALI LNDINPLGKY RMDLVLQLKN NASKLLLAIM ESRHDSENAE RILFNMRPRE
     LVDVMKNAYN QGLECDHGDD EGGDGVSPKD VGHNIYILAH QLARHNKLLQ QMLKPGSDPD
     EGDEALKYYA NHTAQIEIVR HDRTMEQIVF PVPNICEYLT RESKCRVFNT TERDEQGSKV
     NDFFQQTEDL YNEMKWQKKI RSNQALFWFS RHISLWGSIS FNLAVFINLA VALFYPFGDD
     GDEGKCLTVL K
//
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