ID   L9VMR3_9EURY            Unreviewed;       179 AA.
AC   L9VMR3;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE            EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN   ORFNames=C496_17542 {ECO:0000313|EMBL:ELY38449.1};
OS   Natronorubrum tibetense GA33.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC   Natrialbaceae; Natronorubrum.
OX   NCBI_TaxID=1114856 {ECO:0000313|EMBL:ELY38449.1, ECO:0000313|Proteomes:UP000011599};
RN   [1] {ECO:0000313|EMBL:ELY38449.1, ECO:0000313|Proteomes:UP000011599}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GA33 {ECO:0000313|EMBL:ELY38449.1,
RC   ECO:0000313|Proteomes:UP000011599};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
CC   -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC       {ECO:0000256|RuleBase:RU004474}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ELY38449.1}.
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DR   EMBL; AOHW01000042; ELY38449.1; -; Genomic_DNA.
DR   RefSeq; WP_006091558.1; NZ_KB913017.1.
DR   AlphaFoldDB; L9VMR3; -.
DR   STRING; 1114856.GCA_000383975_00183; -.
DR   PATRIC; fig|1114856.3.peg.3637; -.
DR   eggNOG; arCOG01490; Archaea.
DR   OrthoDB; 198183at2157; -.
DR   Proteomes; UP000011599; Unassembled WGS sequence.
DR   GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
DR   CDD; cd00209; DHFR; 1.
DR   Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR   InterPro; IPR012259; DHFR.
DR   InterPro; IPR024072; DHFR-like_dom_sf.
DR   InterPro; IPR017925; DHFR_CS.
DR   InterPro; IPR001796; DHFR_dom.
DR   PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR   PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR   Pfam; PF00186; DHFR_1; 1.
DR   PIRSF; PIRSF000194; DHFR; 1.
DR   PRINTS; PR00070; DHFR.
DR   SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR   PROSITE; PS00075; DHFR_1; 1.
DR   PROSITE; PS51330; DHFR_2; 1.
PE   3: Inferred from homology;
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          14..179
FT                   /note="DHFR"
FT                   /evidence="ECO:0000259|PROSITE:PS51330"
SQ   SEQUENCE   179 AA;  19893 MW;  2E45A1D2903D1242 CRC64;
     MSETESPALE TDRELVGIVA VAENGVIGKD GDMPWHIPAD LQHFKKTTMD HPVIMGRVTY
     EGILEVLGEP LPGRTTIVLT SRDLETPENA VVAGSLEEAL EKADAAARER HDDADRLFVA
     GGATVYEQFL PALDRLVVTE IHDDPDGDTR FPDWDRDAFE TVSRDERDGF GFLEYARRE
//