ID   L9VR56_9EURY            Unreviewed;       352 AA.
AC   L9VR56;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   SubName: Full=CaCA family Na+/Ca+ antiporter {ECO:0000313|EMBL:ELY39695.1};
GN   ORFNames=C496_13496 {ECO:0000313|EMBL:ELY39695.1};
OS   Natronorubrum tibetense GA33.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC   Natrialbaceae; Natronorubrum.
OX   NCBI_TaxID=1114856 {ECO:0000313|EMBL:ELY39695.1, ECO:0000313|Proteomes:UP000011599};
RN   [1] {ECO:0000313|EMBL:ELY39695.1, ECO:0000313|Proteomes:UP000011599}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GA33 {ECO:0000313|EMBL:ELY39695.1,
RC   ECO:0000313|Proteomes:UP000011599};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ELY39695.1}.
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DR   EMBL; AOHW01000036; ELY39695.1; -; Genomic_DNA.
DR   RefSeq; WP_006090629.1; NZ_KB913017.1.
DR   AlphaFoldDB; L9VR56; -.
DR   STRING; 1114856.GCA_000383975_03125; -.
DR   PATRIC; fig|1114856.3.peg.2809; -.
DR   eggNOG; arCOG02881; Archaea.
DR   OrthoDB; 142185at2157; -.
DR   Proteomes; UP000011599; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR   InterPro; IPR004481; K/Na/Ca-exchanger.
DR   InterPro; IPR004837; NaCa_Exmemb.
DR   InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR   NCBIfam; TIGR00367; calcium/sodium antiporter; 1.
DR   PANTHER; PTHR10846:SF8; INNER MEMBRANE PROTEIN YRBG; 1.
DR   PANTHER; PTHR10846; SODIUM/POTASSIUM/CALCIUM EXCHANGER; 1.
DR   Pfam; PF01699; Na_Ca_ex; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        40..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        108..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        132..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        214..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        241..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        272..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        309..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          6..143
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
FT   DOMAIN          214..341
FT                   /note="Sodium/calcium exchanger membrane region"
FT                   /evidence="ECO:0000259|Pfam:PF01699"
FT   REGION          181..200
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   352 AA;  35296 MW;  83ADA6362EA299D0 CRC64;
     MGVLESVALL VVGTIALWLG ATWLVAAASR LAESVGISPL VVGLTVVAFG TSAPEIAVST
     TAALEGQSDV AVGNVVGSNV FNLGVILGIV ALLAPFRVTT TLLRRDALVM AGATVIAALV
     LADQSVSRLE GALLLVLLFG YLGALGMAIR RSSASDSSTE AGDSDGGTAI EEVEEIDSPE
     IEAIGGTGDE NGAVTDETAT AEDSVRLGRE GLRLLLGLAL VVLGGRILVV SATTITLSFG
     ISPWLVGVTI VAAGTSLPEL VTAVVATRRG GVAIAAGNII GSNVFNLLGV LGLAAVVRPM
     TVDPAVFPGV IWLVALTVVA TGLLATGRRV TRLEGGLLVA IGSSYWVVTA AG
//