ID L9VVM4_9EURY Unreviewed; 1253 AA.
AC L9VVM4;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=C496_10226 {ECO:0000313|EMBL:ELY41061.1};
OS Natronorubrum tibetense GA33.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natronorubrum.
OX NCBI_TaxID=1114856 {ECO:0000313|EMBL:ELY41061.1, ECO:0000313|Proteomes:UP000011599};
RN [1] {ECO:0000313|EMBL:ELY41061.1, ECO:0000313|Proteomes:UP000011599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GA33 {ECO:0000313|EMBL:ELY41061.1,
RC ECO:0000313|Proteomes:UP000011599};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELY41061.1}.
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DR EMBL; AOHW01000029; ELY41061.1; -; Genomic_DNA.
DR RefSeq; WP_006089878.1; NZ_KB913017.1.
DR AlphaFoldDB; L9VVM4; -.
DR STRING; 1114856.GCA_000383975_02469; -.
DR PATRIC; fig|1114856.3.peg.2129; -.
DR eggNOG; arCOG00787; Archaea.
DR eggNOG; arCOG00802; Archaea.
DR OrthoDB; 203178at2157; -.
DR Proteomes; UP000011599; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 22..445
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 466..746
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 932..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1015..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 43..50
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1253 AA; 140234 MW; F99B64D63E9ED089 CRC64;
MDNPNRDRNV DTDDGNSESD SLEPQGNQPA VIDSDAACTS VDAGAGTGKT TTMLMRIERA
IERGDADPED VLVLTFANEA AGSIRDAVAD RLDPEAAAAI DVYTYHSFCY RLVREYAYYL
GYSPEFDVVT ERKRRRIVGR LLATNDYDFA TVGQGSPDDL AAGVDRFIQA MSQEDITPEQ
LEAQLPAVRT LELCNEFVLW LERTAGDELS FDNEALRYFN ADDHLEASRQ SLVGYGKLIT
YCREKIAEAP AEFRDEDVVR DVDRYLRVLQ QCVTNTIDVL SLEEPTTKQL PRALFGNEIW
RTATSRIEQS PFGRLKHYVE FMRLARHYTA VYADYHEHLE EERTLDFDEL VRTATELLTD
DDIATEITDQ WTQVYCDEFQ DTDETQFALI TELTDGPDRP DLLAIGDKDQ AIYGWRGTDR
EGLDGLADAY DEHEAIELEL NFRSRQEILD LTNHCDYGPQ SSKTLREVGR ASGEYGSGAD
GENENGDDTT DENGDGDAER LSDRVVKVES DEIDRSTAEQ VATTVSRLLN DEAENVPKRS
LEDIAVIVRT NRHAQAVADE LRNRQIPYEI SGSPRGEISP GMQTLLSYFR VLVDPTADAH
LRRVLLYRYR FTESDLATLQ QRDGSLYDAV LDCEQAELDH PDRLERVRDQ FIELETLRDV
YPLSGFVRRF REVTRLEWFL TTDEREEFQR IERFVEAYTA DSVVQTLTPA FVDALEGTLR
GSGSERTRGT QSSDSVDVMT VHQAKGLEFD TVLVPYLSDE EWCVDRDYAE RARYRLLAAT
LDDDVDSPLL ADLAAETVGE EWRVLHVALT RAENHLFIFG AEYEYDGDET ELGVSTAESC
LSTEIEWSVA GQRMTLWTSL IESFRRVRET YPKTVVDRTA EIGRSAGSSP GTITYYAGYE
DRFVEPLETR EAIETVHRLG RQLRSGTLLP AADAASHGGS ATAGSVEGST RRVPSGRRPS
ALSTDTVRFP VETLSNATEV PAALRHSYTA METHETCARK HYLDHVVRAV DDANGSSVAS
TDEGNEGDHR TGSRTVGTVF HDVAEEAFYR DYRSREEWRE AAVRQLTARD LLEHREAVLA
CVDRYFEATA PAFDERVADW EQLAAELPFA LEDVSGVDGE VVGFVDSVRR TPEGDVVILD
YKATADRIDP GEATQLALYA RACERLFDES VAAVGYVYVG AVDGPRVDLV TPAELPAWSS
VRETLEAVDD PSFDETTPGE HCRYCPHRSL GCGPEADTAD TLDMSGSDPA ADD
//
