ID L9WB32_9EURY Unreviewed; 1172 AA.
AC L9WB32;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=C495_06213 {ECO:0000313|EMBL:ELY46679.1};
OS Natronorubrum sulfidifaciens JCM 14089.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natronorubrum.
OX NCBI_TaxID=1230460 {ECO:0000313|EMBL:ELY46679.1, ECO:0000313|Proteomes:UP000011661};
RN [1] {ECO:0000313|EMBL:ELY46679.1, ECO:0000313|Proteomes:UP000011661}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 14089 {ECO:0000313|EMBL:ELY46679.1,
RC ECO:0000313|Proteomes:UP000011661};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELY46679.1}.
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DR EMBL; AOHX01000029; ELY46679.1; -; Genomic_DNA.
DR RefSeq; WP_008161022.1; NZ_AOHX01000029.1.
DR AlphaFoldDB; L9WB32; -.
DR STRING; 1230460.C495_06213; -.
DR PATRIC; fig|1230460.4.peg.1249; -.
DR eggNOG; arCOG00439; Archaea.
DR eggNOG; arCOG03155; Archaea.
DR eggNOG; arCOG03156; Archaea.
DR OrthoDB; 6747at2157; -.
DR Proteomes; UP000011661; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR CDD; cd00081; Hint; 2.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 2.
DR Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR003586; Hint_dom_C.
DR InterPro; IPR003587; Hint_dom_N.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR006142; INTEIN.
DR InterPro; IPR030934; Intein_C.
DR InterPro; IPR004042; Intein_endonuc.
DR InterPro; IPR006141; Intein_N.
DR InterPro; IPR004860; LAGLIDADG_2.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR048907; MCM_WH.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR01443; intein_Cterm; 1.
DR NCBIfam; TIGR01445; intein_Nterm; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF43; DNA REPLICATION LICENSING FACTOR MCM6; 1.
DR Pfam; PF01381; HTH_3; 1.
DR Pfam; PF14890; Intein_splicing; 1.
DR Pfam; PF14528; LAGLIDADG_3; 2.
DR Pfam; PF00493; MCM; 2.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR Pfam; PF21120; MCM_WH_arc; 1.
DR PRINTS; PR00379; INTEIN.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00305; HintC; 1.
DR SMART; SM00306; HintN; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR SUPFAM; SSF55608; Homing endonucleases; 2.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
DR PROSITE; PS50818; INTEIN_C_TER; 1.
DR PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR PROSITE; PS50817; INTEIN_N_TER; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW Cell cycle {ECO:0000313|EMBL:ELY46679.1};
KW Cell division {ECO:0000313|EMBL:ELY46679.1};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Protein splicing {ECO:0000256|ARBA:ARBA00023000};
KW Reference proteome {ECO:0000313|Proteomes:UP000011661}.
FT DOMAIN 277..333
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT DOMAIN 486..626
FT /note="DOD-type homing endonuclease"
FT /evidence="ECO:0000259|PROSITE:PS50819"
FT DOMAIN 687..731
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
FT DOMAIN 784..806
FT /note="Intein C-terminal splicing"
FT /evidence="ECO:0000259|PROSITE:PS50818"
FT DOMAIN 806..957
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT COILED 1104..1158
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1172 AA; 131695 MW; FD09F61F4E2E071D CRC64;
MAQAGNSELV DSFEQFFRNY YDNEIKQLAQ RYPNEQRSLH VDWQDLYRFD PDLADDVLNQ
PEQLQRYAEE ALRLYDLPID VSLGQAHVRI RNLPETESPE IRDIRARDMN SLVQVHGIVR
KATDVRPKIE EAAFECQLCG TLNRIPQSSG DFQEPHECQG CERQGPFKVN FDQSEFVDSQ
KLRMQESPEG LRGGETPQSL DVHIEDDITG EVTPGDHVSA TGVLRLEQQG NDQEKSPVFD
FYMEGMSVDV DEEQFEDMDI TDEDKEEIVR LSSSEDIYEK MVASIAPSIY GYDQEKLAMI
LQLFSGVTKQ LPDGSRIRGD LHMLLIGDPG TGKCVHGDTK ITLADGRNVP IREIVESNLE
DPKPIDDGWY DEIDFNIPSL QDNGSIAPQR ATKVWKREAP DQMYRIRTSS GRELEVTPSH
PLFVQNDGQL KPIIADDLTT GQFIAAPRTL TVDGDDTLNV DFRQSRSPNA VQLDLPSQWT
PSLARLIGYI IAEGYVQQRD DNTGFVSITN NDREVLDDAT DALKKLGLNT TERVPHESKD
ASELLCSAGE FVSFLEVLEP CILQPSSEQC VPDSIFEASA TIKSEFLKAF IEGEGHVSES
QRELTVASMS RNLLEDVRTL LLSVGIRSQL HQRQNSSCRL RISGNEFERY VSKVGFITQR
KQQAAEQYAD TMRNTNRDVI PDIGSELRRI RESLSLTQAE CGLPRSTYQH YERGSRNPSR
ESFEKVVSTF KDALSAEEAP RENGVLADGG SLKRSLNTLE QFAEGDVCWE RIESISSVEP
DYDWVYDLEV EGTHNYISNG VISHNSQMLG YIKNIAPRAV YTSGKGSSSA GLTAAAVRDD
FGDGQQWTLE AGALVLADRG IAAVDELDKM RSEDRSAMHE ALEQQKISVS KAGINATLKS
RCSLLGAANP KYGRFDHYEP ISEQIDLEPA LVSRFDLIFT VTDDPDEEKD RNLAEHILTT
NYAGELTTQR EQMTSMDVSD EEIEAMTGQV DPEIDAELLR KYIAYAKQNC HPRMTEEARE
AIREFYVDLR LKGTDEDAPI PVTARKLEAL VRLSEASARV RLSDTVEQHD AERVIEIVRS
CLQDIGVDPE TGEFDADIVE AGTSKSQRDR IKNIKQLISD IEAEYDDGAP VDIVLDRAEE
IGMDHSKAEH EIEKLKQKGE VYEPSMDNLR TT
//
