ID L9X2F7_9EURY Unreviewed; 685 AA.
AC L9X2F7;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=DNA-binding protein MutS2 {ECO:0000256|HAMAP-Rule:MF_00971};
GN Name=mutS2 {ECO:0000256|HAMAP-Rule:MF_00971};
GN ORFNames=C493_12409 {ECO:0000313|EMBL:ELY54773.1};
OS Natronolimnohabitans innermongolicus JCM 12255.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC Natrialbaceae; Natronolimnohabitans.
OX NCBI_TaxID=1227499 {ECO:0000313|EMBL:ELY54773.1, ECO:0000313|Proteomes:UP000011602};
RN [1] {ECO:0000313|EMBL:ELY54773.1, ECO:0000313|Proteomes:UP000011602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 12255 {ECO:0000313|EMBL:ELY54773.1,
RC ECO:0000313|Proteomes:UP000011602};
RX PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT strategies for static and dynamic osmo-response.";
RL PLoS Genet. 10:E1004784-E1004784(2014).
CC -!- FUNCTION: Has ATPase and non-specific DNA-binding activities.
CC {ECO:0000256|HAMAP-Rule:MF_00971}.
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00971};
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. Archaeal
CC Muts2 subfamily. {ECO:0000256|HAMAP-Rule:MF_00971}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ELY54773.1}.
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DR EMBL; AOHZ01000055; ELY54773.1; -; Genomic_DNA.
DR RefSeq; WP_007259760.1; NZ_AOHZ01000055.1.
DR AlphaFoldDB; L9X2F7; -.
DR STRING; 1227499.C493_12409; -.
DR PATRIC; fig|1227499.3.peg.2548; -.
DR eggNOG; arCOG02895; Archaea.
DR OrthoDB; 15514at2157; -.
DR Proteomes; UP000011602; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00971; MutS2_archaea; 1.
DR InterPro; IPR012401; DNA-bd_MutS2_arc.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010994; RuvA_2-like.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF125; DNA-BINDING PROTEIN MUTS2; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF029254; MutS_C_archaeal; 1.
DR SMART; SM00534; MUTSac; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00971};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00971}; Hydrolase {ECO:0000256|HAMAP-Rule:MF_00971};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00971}; Reference proteome {ECO:0000313|Proteomes:UP000011602}.
FT DOMAIN 478..655
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|SMART:SM00534"
FT REGION 652..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 485..492
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00971"
SQ SEQUENCE 685 AA; 73931 MW; 733E95BCED7B54FA CRC64;
MDLETIPGVG EKTARALAAL DEPERALRRG DVATISTAPG ISQGRAARIA RGAIRLEHDD
PGGFLATDRA REIYRDVLGL LQERTVTDYA AQRLETIYPS PRRSRIEEVQ TFAAEAVERE
YDAAVLEALE GVEPLRKPGD VRVRERCLAT TDAERYSAAR EAIPELSVEV VEDAQGLAEL
ARGYATVYAL DESFAGVTVE GDVQVTPDAL ENPAEVVPER PLAFFARNRD RLQAAVEVHR
TAALEPACDL AALEDGLARL DEDGTVAGDE ELDRLTTAVD DLDAAASAAE SVANDRLREA
IREQDVTIEG SDLLSLVERG AGVDSLLSRE LADEYAVAVE AAREHLIDAL DLDQGEAEVA
RRAFSDEPTF PVERDEEVIS RLREELTAAK ERRAGRLKRE LAADLADQRE GARQLVRDAL
ELDVELAVAR FAREYECTMP AFVSDDDADA VGFAIEGGRS PLLDEPLAEI DPVDYDVSGV
ALLSGVNSGG KTSTLDLVAS VVVLAHMGLP VPADRVRLRR FDDLHYHAKT QGTLDAGAFE
STVREFADLA QGGEGSLVLV DELESITEPG ASAKIIAGIL EALSENDATA VFVSHLAGEI
REMADYDVTV DGIEAVGLVD GELEVNRSPV KDHLARSTPE LIVEKLADEA RDEQVAANGG
APASDGSADR EPEPVFYDRL LEKFD
//
