ID   L9XE28_9EURY            Unreviewed;       685 AA.
AC   L9XE28;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE            EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN   ORFNames=C493_04538 {ECO:0000313|EMBL:ELY59970.1};
OS   Natronolimnohabitans innermongolicus JCM 12255.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Natrialbales;
OC   Natrialbaceae; Natronolimnohabitans.
OX   NCBI_TaxID=1227499 {ECO:0000313|EMBL:ELY59970.1, ECO:0000313|Proteomes:UP000011602};
RN   [1] {ECO:0000313|EMBL:ELY59970.1, ECO:0000313|Proteomes:UP000011602}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 12255 {ECO:0000313|EMBL:ELY59970.1,
RC   ECO:0000313|Proteomes:UP000011602};
RX   PubMed=25393412; DOI=10.1371/journal.pgen.1004784;
RA   Becker E.A., Seitzer P.M., Tritt A., Larsen D., Krusor M., Yao A.I., Wu D.,
RA   Madern D., Eisen J.A., Darling A.E., Facciotti M.T.;
RT   "Phylogenetically driven sequencing of extremely halophilic archaea reveals
RT   strategies for static and dynamic osmo-response.";
RL   PLoS Genet. 10:E1004784-E1004784(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ELY59970.1}.
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DR   EMBL; AOHZ01000020; ELY59970.1; -; Genomic_DNA.
DR   RefSeq; WP_007258215.1; NZ_AOHZ01000020.1.
DR   AlphaFoldDB; L9XE28; -.
DR   STRING; 1227499.C493_04538; -.
DR   PATRIC; fig|1227499.3.peg.930; -.
DR   eggNOG; arCOG01529; Archaea.
DR   OrthoDB; 371752at2157; -.
DR   Proteomes; UP000011602; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ELY59970.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011602}.
FT   DOMAIN          35..86
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          89..475
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          570..648
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   685 AA;  76025 MW;  FE4448DC41C7B931 CRC64;
     MSQEDADLEA RLEEQETFEP PESFVEQANV TDPGIYEEFE ENWPDCWERA ADLLSWDEAY
     DTVLEDGDAP FYEWFTGGEL NASYNCLDRH VEEGRGDEAA IEWEGELGET RTYTYSELLD
     EVESFAATLR DLGVEEDDVV TLYMPMVPEL PVAMLACARI GAPHSVVFAG FSADALATRM
     NSAESEYLVT CDGYYRRGDA LDHIAKANEG LADVEHEVSD VVVVDRLGDD LEHDLADNQH
     DYDDLVDEHA DASVDPVSRD AEDMLFLMYT SGTTGQPKGV KHTTGGYLAY TAWTARAVLD
     LEADDTYWCS ADIGWITGHS YIVYGPLALG TTSVMYEGTP DYPNKDRFWE IVEKNEVDVF
     YTAPTAIRAF MKWGEEYPEK RDLSSLRLLG TVGEPINPRA WKWYYKHIGN EECPIVDTWW
     QTETGGHMIT TLPGVNDMKP GSAGPGLPGV DIQVVDAQGE EVEAGEAGYL TVPKPWPGML
     RTLYQNDERF IDEYWQEYSD PDADEWVYFP EDGAKIDEDG YITVLGRVDD VINVSFPEDG
     AKIDEDGYIT VLGRVDDVIN VSGHRLGTME VESAIVGVEG VAEAAVVGGD HDVKGEAVYA
     YVITEDGYDG DSDLESEIID GVVDAIGPIA KPEEVIFTPE LPKTRSGKIM RRLLENIASG
     NELGDTSTLR NPEIVDEIAQ QVEAD
//