ID LAB_DROME Reviewed; 635 AA.
AC P10105; O97065;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2002, sequence version 2.
DT 24-JAN-2024, entry version 205.
DE RecName: Full=Homeotic protein labial;
DE AltName: Full=F24;
DE AltName: Full=F90-2;
GN Name=lab; ORFNames=CG1264;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], ALTERNATIVE SPLICING, TISSUE
RP SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=Oregon-R; TISSUE=Embryo;
RX PubMed=2461299; DOI=10.1002/j.1460-2075.1988.tb03106.x;
RA Mlodzik M., Fjose A., Gehring W.J.;
RT "Molecular structure and spatial expression of a homeobox gene from the
RT labial region of the Antennapedia-complex.";
RL EMBO J. 7:2569-2578(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE (ISOFORM SHORT), AND CHARACTERIZATION.
RC STRAIN=Canton-S, and Oregon-R; TISSUE=Embryo;
RX PubMed=2566560; DOI=10.1101/gad.3.3.399;
RA Diederich R.J., Merrill V.K.L., Pultz M.A., Kaufman T.C.;
RT "Isolation, structure, and expression of labial, a homeotic gene of the
RT Antennapedia Complex involved in Drosophila head development.";
RL Genes Dev. 3:399-414(1989).
RN [3]
RP NUCLEOTIDE SEQUENCE (ISOFORM SHORT).
RC STRAIN=Berkeley;
RA Celniker S.E., Pfeiffer B., Knafels J., Martin C.H., Mayeda C.A.,
RA Palazzolo M.J.;
RT "Complete sequence of the Antennapedia complex of Drosophila.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM SHORT).
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT).
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=10731138; DOI=10.1126/science.287.5461.2222;
RA Rubin G.M., Hong L., Brokstein P., Evans-Holm M., Frise E., Stapleton M.,
RA Harvey D.A.;
RT "A Drosophila complementary DNA resource.";
RL Science 287:2222-2224(2000).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 500-567, AND TISSUE SPECIFICITY.
RC STRAIN=Canton-S;
RX PubMed=3014511; DOI=10.1073/pnas.83.13.4809;
RA Hoey T., Doyle H.J., Harding K., Wedeen C., Levine M.;
RT "Homeo box gene expression in anterior and posterior regions of the
RT Drosophila embryo.";
RL Proc. Natl. Acad. Sci. U.S.A. 83:4809-4813(1986).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. Required for
CC proper head development.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=P10105-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=P10105-2; Sequence=VSP_002397;
CC -!- TISSUE SPECIFICITY: During embryogenesis, expressed in mandibular lobe,
CC hypopharyngeal organ, neural and epidermal cells of procephalic lobe,
CC sensory cells of clypeolabrum, posterior midgut, thoracic and abdominal
CC segments. {ECO:0000269|PubMed:2461299, ECO:0000269|PubMed:3014511}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. High
CC expression in embryos and third instar larvae, lower expression in
CC pupae. {ECO:0000269|PubMed:2461299}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Labial subfamily.
CC {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1, Met-2 or Met-7 is the
CC initiator. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X13103; CAA31495.1; -; mRNA.
DR EMBL; X13104; CAB57786.1; -; Genomic_DNA.
DR EMBL; X13105; CAB57786.1; JOINED; Genomic_DNA.
DR EMBL; X13106; CAB57786.1; JOINED; Genomic_DNA.
DR EMBL; X13104; CAB57787.1; -; Genomic_DNA.
DR EMBL; X13105; CAB57787.1; JOINED; Genomic_DNA.
DR EMBL; X13106; CAB57787.1; JOINED; Genomic_DNA.
DR EMBL; AE001572; AAD19811.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF54098.1; -; Genomic_DNA.
DR EMBL; AY095089; AAM11417.1; -; mRNA.
DR EMBL; M13570; AAA28610.1; -; Genomic_DNA.
DR PIR; A30168; A30168.
DR PIR; S01164; S01164.
DR RefSeq; NP_476613.1; NM_057265.4. [P10105-2]
DR AlphaFoldDB; P10105; -.
DR SMR; P10105; -.
DR BioGRID; 66015; 11.
DR DIP; DIP-59868N; -.
DR IntAct; P10105; 2.
DR STRING; 7227.FBpp0081194; -.
DR PaxDb; 7227-FBpp0081194; -.
DR DNASU; 40817; -.
DR EnsemblMetazoa; FBtr0081696; FBpp0081194; FBgn0002522. [P10105-2]
DR GeneID; 40817; -.
DR KEGG; dme:Dmel_CG1264; -.
DR UCSC; CG1264-RA; d. melanogaster. [P10105-1]
DR AGR; FB:FBgn0002522; -.
DR CTD; 40817; -.
DR FlyBase; FBgn0002522; lab.
DR VEuPathDB; VectorBase:FBgn0002522; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000174017; -.
DR HOGENOM; CLU_433673_0_0_1; -.
DR InParanoid; P10105; -.
DR OMA; MHAHMHH; -.
DR OrthoDB; 728401at2759; -.
DR SignaLink; P10105; -.
DR BioGRID-ORCS; 40817; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 40817; -.
DR PRO; PR:P10105; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0002522; Expressed in embryonic procephalic segment and 34 other cell types or tissues.
DR ExpressionAtlas; P10105; baseline and differential.
DR Genevisible; P10105; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IPI:FlyBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IMP:FlyBase.
DR GO; GO:0035284; P:brain segmentation; IGI:FlyBase.
DR GO; GO:0030154; P:cell differentiation; TAS:FlyBase.
DR GO; GO:0001709; P:cell fate determination; TAS:FlyBase.
DR GO; GO:0060323; P:head morphogenesis; IMP:FlyBase.
DR GO; GO:0007494; P:midgut development; TAS:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046327; HXA1/B1/D1.
DR PANTHER; PTHR45946; HOMEOBOX PROTEIN ROUGH-RELATED; 1.
DR PANTHER; PTHR45946:SF4; HOMEOBOX PROTEIN ROUGH-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..635
FT /note="Homeotic protein labial"
FT /id="PRO_0000200262"
FT DNA_BIND 507..566
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 39..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 584..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 406..411
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000303|PubMed:10731138"
FT /id="VSP_002397"
FT CONFLICT 31
FT /note="S -> A (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 46
FT /note="P -> H (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 139
FT /note="T -> K (in Ref. 1; CAB57786/CAB57787)"
FT /evidence="ECO:0000305"
FT CONFLICT 444
FT /note="G -> D (in Ref. 1; CAA31495/CAB57786/CAB57787)"
FT /evidence="ECO:0000305"
FT CONFLICT 447
FT /note="N -> S (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 635 AA; 68154 MW; B39A58813F4D5778 CRC64;
MMDVSSMYGN HPHHHHPHAN AYDGYSTTTA SAANASSYFA PQQHQPHLQL QQQQQHQHLQ
QPQQHLTYNG YESSSPGNYY PQQQAQLTPP PTSSHQVVQQ HQQQQQAQQQ QLYPHSHLFS
PSAAEYGITT STTTGNPGTP LHPSSHSPAD SYYESDSVHS YYATAAVATV APPSNSSPIT
AANASATSNT QQQQQQAAII SSENGMMYTN LDCMYPTAQA QAPVHGYAGQ IEEKYAAVLH
ASYAPGMVLE DQDPMMQQAT QSQMWHHQQH LAGSYALDAM DSLGMHAHMH HGLPHGHLGN
LANNPHQQQP QVQQQQQQPH QQPQHPQNQS PAAHQQHHQN SVSPNGGMNR QQRGGVISPG
SSTSSSTSAS NGAHPASTQS KSPNHSSSIP TYKWMQLKRN VPKPQAPSYL PAPKLPASGI
ASMHDYQMNG QLDMCRGGGG GGSGVGNGPV GVGGNGSPGI GGVLSVQNSL IMANSAAAAG
SAHPNGMGVG LGSGSGLSSC SLSSNTNNSG RTNFTNKQLT ELEKEFHFNR YLTRARRIEI
ANTLQLNETQ VKIWFQNRRM KQKKRVKEGL IPADILTQHS TSVISEKPPQ QQQPQPPELQ
LKSQGSDLGG NELATGAPST PTTAMTLTAP TSKQS
//
