ID LACA_ENTFA Reviewed; 142 AA.
AC Q833U3;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=Galactose-6-phosphate isomerase subunit LacA {ECO:0000255|HAMAP-Rule:MF_01555};
DE EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01555};
GN Name=lacA {ECO:0000255|HAMAP-Rule:MF_01555}; OrderedLocusNames=EF_1835;
OS Enterococcus faecalis (strain ATCC 700802 / V583).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=226185;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700802 / V583;
RX PubMed=12663927; DOI=10.1126/science.1080613;
RA Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT faecalis.";
RL Science 299:2071-2074(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01555};
CC -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_01555}.
CC -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC {ECO:0000255|HAMAP-Rule:MF_01555}.
CC -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC Rule:MF_01555}.
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DR EMBL; AE016830; AAO81600.1; -; Genomic_DNA.
DR RefSeq; NP_815530.1; NC_004668.1.
DR RefSeq; WP_002357188.1; NZ_KE136528.1.
DR AlphaFoldDB; Q833U3; -.
DR SMR; Q833U3; -.
DR STRING; 226185.EF_1835; -.
DR EnsemblBacteria; AAO81600; AAO81600; EF_1835.
DR GeneID; 60894135; -.
DR KEGG; efa:EF1835; -.
DR PATRIC; fig|226185.45.peg.1685; -.
DR eggNOG; COG0698; Bacteria.
DR HOGENOM; CLU_091396_4_2_9; -.
DR UniPathway; UPA00702; UER00714.
DR Proteomes; UP000001415; Chromosome.
DR GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1400.10; Sugar-phosphate isomerase, RpiB/LacA/LacB; 1.
DR HAMAP; MF_01555; LacA; 1.
DR InterPro; IPR004783; LacA.
DR InterPro; IPR003500; RpiB_LacA_LacB.
DR InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR NCBIfam; TIGR01118; lacA; 1.
DR NCBIfam; TIGR00689; rpiB_lacA_lacB; 1.
DR PANTHER; PTHR30345:SF5; GALACTOSE-6-PHOSPHATE ISOMERASE SUBUNIT LACA; 1.
DR PANTHER; PTHR30345; RIBOSE-5-PHOSPHATE ISOMERASE B; 1.
DR Pfam; PF02502; LacAB_rpiB; 1.
DR PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR SUPFAM; SSF89623; Ribose/Galactose isomerase RpiB/AlsB; 1.
PE 3: Inferred from homology;
KW Isomerase; Lactose metabolism; Reference proteome.
FT CHAIN 1..142
FT /note="Galactose-6-phosphate isomerase subunit LacA"
FT /id="PRO_0000208103"
SQ SEQUENCE 142 AA; 15605 MW; B510BB7E8E4881FA CRC64;
MRVILGSDLD GIKLKAEMKQ YLLQEKVEVI DKSESASEDF IEATLAVAHE VLKDTESLGI
VFDGYGAGSF MTAAKIKGMI VAELSDERSA YMAREHNNAR MITVGAKIVG TELAKNIIKE
FLTGHYAGGR HQIRVDMLNK MA
//
