ID LACB_STAEQ Reviewed; 171 AA.
AC Q5HM36;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=Galactose-6-phosphate isomerase subunit LacB {ECO:0000255|HAMAP-Rule:MF_01556};
DE EC=5.3.1.26 {ECO:0000255|HAMAP-Rule:MF_01556};
GN Name=lacB {ECO:0000255|HAMAP-Rule:MF_01556}; OrderedLocusNames=SERP1794;
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01556};
CC -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC {ECO:0000255|HAMAP-Rule:MF_01556}.
CC -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC {ECO:0000255|HAMAP-Rule:MF_01556}.
CC -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000255|HAMAP-
CC Rule:MF_01556}.
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DR EMBL; CP000029; AAW55179.1; -; Genomic_DNA.
DR RefSeq; WP_001829777.1; NC_002976.3.
DR AlphaFoldDB; Q5HM36; -.
DR SMR; Q5HM36; -.
DR STRING; 176279.SERP1794; -.
DR GeneID; 50018110; -.
DR KEGG; ser:SERP1794; -.
DR eggNOG; COG0698; Bacteria.
DR HOGENOM; CLU_091396_2_0_9; -.
DR UniPathway; UPA00702; UER00714.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1400.10; Sugar-phosphate isomerase, RpiB/LacA/LacB; 1.
DR HAMAP; MF_01556; LacB; 1.
DR InterPro; IPR004784; LacB.
DR InterPro; IPR003500; RpiB_LacA_LacB.
DR InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR NCBIfam; TIGR01119; lacB; 1.
DR NCBIfam; TIGR00689; rpiB_lacA_lacB; 1.
DR PANTHER; PTHR30345:SF0; DNA DAMAGE-REPAIR_TOLERATION PROTEIN DRT102; 1.
DR PANTHER; PTHR30345; RIBOSE-5-PHOSPHATE ISOMERASE B; 1.
DR Pfam; PF02502; LacAB_rpiB; 1.
DR PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR SUPFAM; SSF89623; Ribose/Galactose isomerase RpiB/AlsB; 1.
PE 3: Inferred from homology;
KW Isomerase; Lactose metabolism; Reference proteome.
FT CHAIN 1..171
FT /note="Galactose-6-phosphate isomerase subunit LacB"
FT /id="PRO_0000208144"
SQ SEQUENCE 171 AA; 18903 MW; 0CF3B0A59420B477 CRC64;
MKIAIGCDHI VTDTKMEVSQ HLKSQGHEVI DVGTYDFTRT HYPIYGKKVG EKVASGEADL
GVCICGTGVG ISNAANKVPG VRTALVRDMT SALYSKEELN ANVVSFGGKV AGELFIFDIV
DAFIEAEYKP TEENKKLIAK INHLEAHNND QADPHFFDEF LEKWNKGEYH D
//
