GenomeNet

Database: UniProt
Entry: LAP1_DROME
LinkDB: LAP1_DROME
Original site: LAP1_DROME 
ID   LAP1_DROME              Reviewed;         849 AA.
AC   Q9V780;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   27-MAR-2024, entry version 153.
DE   RecName: Full=Protein lap1;
GN   Name=Lap1 {ECO:0000312|EMBL:AAF58179.1}; ORFNames=CG10255;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1] {ECO:0000312|EMBL:AAF58179.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:AAF58179.1}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3] {ECO:0000312|EMBL:AAR96157.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley {ECO:0000312|EMBL:AAR96157.1}; TISSUE=Embryo;
RA   Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA   Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May have a role in assembling adherens junctions.
CC       {ECO:0000250|UniProtKB:O61967}.
CC   -!- SIMILARITY: Belongs to the LAP (LRR and PDZ) protein family.
CC       {ECO:0000305}.
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DR   EMBL; AE013599; AAF58179.1; -; Genomic_DNA.
DR   EMBL; BT011365; AAR96157.1; -; mRNA.
DR   RefSeq; NP_001188938.1; NM_001202009.2.
DR   RefSeq; NP_611007.1; NM_137163.5.
DR   AlphaFoldDB; Q9V780; -.
DR   SMR; Q9V780; -.
DR   BioGRID; 62412; 6.
DR   IntAct; Q9V780; 2.
DR   STRING; 7227.FBpp0086538; -.
DR   PaxDb; 7227-FBpp0086538; -.
DR   DNASU; 36670; -.
DR   EnsemblMetazoa; FBtr0087407; FBpp0086538; FBgn0033984.
DR   EnsemblMetazoa; FBtr0303759; FBpp0292771; FBgn0033984.
DR   GeneID; 36670; -.
DR   KEGG; dme:Dmel_CG10255; -.
DR   UCSC; CG10255-RA; d. melanogaster.
DR   AGR; FB:FBgn0033984; -.
DR   CTD; 36670; -.
DR   FlyBase; FBgn0033984; Lap1.
DR   VEuPathDB; VectorBase:FBgn0033984; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   HOGENOM; CLU_336254_0_0_1; -.
DR   InParanoid; Q9V780; -.
DR   OMA; ACKHLTH; -.
DR   OrthoDB; 2909504at2759; -.
DR   PhylomeDB; Q9V780; -.
DR   SignaLink; Q9V780; -.
DR   BioGRID-ORCS; 36670; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 36670; -.
DR   PRO; PR:Q9V780; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   Bgee; FBgn0033984; Expressed in brain and 25 other cell types or tissues.
DR   ExpressionAtlas; Q9V780; baseline and differential.
DR   Genevisible; Q9V780; DM.
DR   GO; GO:0007163; P:establishment or maintenance of cell polarity; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; ISS:UniProtKB.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   PANTHER; PTHR23119; DISCS LARGE; 1.
DR   PANTHER; PTHR23119:SF50; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00560; LRR_1; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   Pfam; PF00595; PDZ; 1.
DR   SMART; SM00364; LRR_BAC; 10.
DR   SMART; SM00369; LRR_TYP; 13.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF52058; L domain-like; 2.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   PROSITE; PS51450; LRR; 13.
DR   PROSITE; PS50106; PDZ; 1.
PE   2: Evidence at transcript level;
KW   Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..849
FT                   /note="Protein lap1"
FT                   /id="PRO_0000188306"
FT   REPEAT          18..39
FT                   /note="LRR 1"
FT   REPEAT          41..62
FT                   /note="LRR 2"
FT   REPEAT          64..85
FT                   /note="LRR 3"
FT   REPEAT          87..108
FT                   /note="LRR 4"
FT   REPEAT          110..131
FT                   /note="LRR 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          133..155
FT                   /note="LRR 6"
FT   REPEAT          156..177
FT                   /note="LRR 7"
FT   REPEAT          179..200
FT                   /note="LRR 8"
FT   REPEAT          202..224
FT                   /note="LRR 9"
FT   REPEAT          225..246
FT                   /note="LRR 10"
FT   REPEAT          248..269
FT                   /note="LRR 11"
FT   REPEAT          271..292
FT                   /note="LRR 12"
FT   REPEAT          294..315
FT                   /note="LRR 13"
FT   REPEAT          317..338
FT                   /note="LRR 14"
FT   REPEAT          340..362
FT                   /note="LRR 15"
FT   REPEAT          363..384
FT                   /note="LRR 16"
FT                   /evidence="ECO:0000255"
FT   REPEAT          386..407
FT                   /note="LRR 17"
FT   DOMAIN          770..849
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   REGION          716..752
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        737..752
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   849 AA;  96148 MW;  C86DD96C242080E2 CRC64;
     MPLLSKCFPC FKFKREEVID KLDYSNTPLT DFPEVWQHER TLEELYLSTT RLQALPPQLF
     YCQGLRVLHV NSNNLESIPQ AIGSLRQLQH LDLNRNLIVN VPEEIKSCKH LTHLDLSCNS
     LQRLPDAITS LISLQELLLN ETYLEFLPAN FGRLVNLRIL ELRLNNLMTL PKSMVRLINL
     QRLDIGGNEF TELPEVVGEL KSLRELWIDF NQIRRVSANI GKLRDLQHFE ANGNLLDTLP
     SELSNWRNVE VLSICSNSLE AFPFSVGMLK SLVTFKCESN GLTELPDSIS YLEQLEELVL
     SHNKLIRLPS TIGMLRSLRF LFADDNQLRQ LPDELCSCQQ LSVLSVANNQ LSALPQNIGN
     LSKMKVLNVV NNYINALPVS MLNLVNLTSM WLSDNQSQPL VPLQYLDAST KTQLTCFMLP
     QVTFKMNSIQ AQQQAQEQYE FVYANQQQPH ASPSRRICFA EEATILSNAK AQPAPNYPSF
     VAAPPTPTPD QMAGSVRLMR SPTPYPKELR QMSKYVRQAQ AATSSANASE VREARVVTNG
     QIHCDSNNAN QDVVDQATTS AIYGIAPETT HIYGVYQQPQ QMAHPVPTQE YYGLPLVNYE
     AHYQQLYVEA NTPLPTTHLN GDQDYELQPL QQQPMQQQAL PTPRLEPPPY HIARVYTKKT
     PEDLNLYESM RQRKQQQQLQ EQTIYQDALN SNSNFKTTAI GAQDVEESVD QLDYQNNISN
     NLEPNPEEED QELDDTMSQH SLNSTATNNT SKASHKKSTW IFGVHKNPTV KQVTLKWENS
     IGFDIAELLN QVGIFVSSIT PNTNAARLLN LNDKLLEIDG YDLTNANLSD AKRVLLNCGT
     VMNIMLSRK
//
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