ID   LEAP2_CAVPO             Reviewed;          71 AA.
AC   Q91X13;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-MAY-2023, entry version 77.
DE   RecName: Full=Liver-expressed antimicrobial peptide 2;
DE            Short=LEAP-2;
DE   Flags: Precursor; Fragment;
GN   Name=LEAP2;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Small intestine;
RX   PubMed=12493837; DOI=10.1110/ps.0213603;
RA   Krause A., Sillard R., Kleemeier B., Kluever E., Maronde E.,
RA   Conejo-Garcia J.-R., Forssmann W.-G., Schulz-Knappe P., Nehls M.C.,
RA   Wattler F., Wattler S., Adermann K.;
RT   "Isolation and biochemical characterization of LEAP-2, a novel blood
RT   peptide expressed in the liver.";
RL   Protein Sci. 12:143-152(2003).
CC   -!- FUNCTION: Has an antimicrobial activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the LEAP2 family. {ECO:0000305}.
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DR   EMBL; AJ409054; CAC51471.1; -; mRNA.
DR   AlphaFoldDB; Q91X13; -.
DR   SMR; Q91X13; -.
DR   STRING; 10141.ENSCPOP00000021028; -.
DR   eggNOG; ENOG502SD5B; Eukaryota.
DR   HOGENOM; CLU_178163_0_0_1; -.
DR   InParanoid; Q91X13; -.
DR   TreeFam; TF336274; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.40.50; -; 1.
DR   InterPro; IPR009955; LEAP-2.
DR   PANTHER; PTHR21007; LIVER EXPRESSED ANTIMICROBIAL PEPTIDE 2; 1.
DR   PANTHER; PTHR21007:SF1; LIVER-EXPRESSED ANTIMICROBIAL PEPTIDE 2; 1.
DR   Pfam; PF07359; LEAP-2; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          <1..16
FT                   /evidence="ECO:0000255"
FT   PROPEP          17..31
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000017353"
FT   CHAIN           32..71
FT                   /note="Liver-expressed antimicrobial peptide 2"
FT                   /id="PRO_0000017354"
FT   DISULFID        48..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..64
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   71 AA;  7943 MW;  1F23ED8495183644 CRC64;
     SVVLLICLLL LGQVDGSPVP EKSSVKKRLR RMTPFWRGVS LRPIGASCRD DSECITRLCK
     KRRCSLSVAQ E
//