ID LET6_SOLLC Reviewed; 355 AA.
AC O22299;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 24-JAN-2024, entry version 120.
DE RecName: Full=Homeobox protein knotted-1-like LET6;
GN Name=LET6;
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. VFNT Cherry;
RX PubMed=9484482; DOI=10.1023/a:1005925508579;
RA Janssen B.-J., Williams A., Chen J.J., Mathern J., Hake S., Sinha N.;
RT "Isolation and characterization of two knotted-like homeobox genes from
RT tomato.";
RL Plant Mol. Biol. 36:417-425(1998).
CC -!- FUNCTION: May have a role to play in formative events in ovule and
CC embryo morphogenesis. Probably binds to the DNA sequence 5'-TGAC-3'.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in developing lateral organs and
CC developing ovaries in flowers.
CC -!- SIMILARITY: Belongs to the TALE/KNOX homeobox family.
CC {ECO:0000255|PROSITE-ProRule:PRU00559}.
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DR EMBL; AF000141; AAC49917.1; -; mRNA.
DR PIR; T04317; T04317.
DR AlphaFoldDB; O22299; -.
DR SMR; O22299; -.
DR STRING; 4081.O22299; -.
DR PaxDb; 4081-Solyc02g081120-2-1; -.
DR eggNOG; KOG0773; Eukaryota.
DR InParanoid; O22299; -.
DR Proteomes; UP000004994; Unplaced.
DR ExpressionAtlas; O22299; baseline and differential.
DR GO; GO:0005768; C:endosome; IEA:EnsemblPlants.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:EnsemblPlants.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:EnsemblPlants.
DR GO; GO:0009506; C:plasmodesma; IEA:EnsemblPlants.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:EnsemblPlants.
DR GO; GO:0003723; F:RNA binding; IEA:EnsemblPlants.
DR GO; GO:0048440; P:carpel development; IEA:EnsemblPlants.
DR GO; GO:0010582; P:floral meristem determinacy; IEA:EnsemblPlants.
DR GO; GO:0009934; P:regulation of meristem structural organization; IEA:EnsemblPlants.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR005539; ELK_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR005540; KNOX1.
DR InterPro; IPR005541; KNOX2.
DR PANTHER; PTHR11850:SF288; HOMEOBOX PROTEIN SHOOT MERISTEMLESS; 1.
DR PANTHER; PTHR11850; HOMEOBOX PROTEIN TRANSCRIPTION FACTORS; 1.
DR Pfam; PF03789; ELK; 1.
DR Pfam; PF05920; Homeobox_KN; 1.
DR Pfam; PF03790; KNOX1; 1.
DR Pfam; PF03791; KNOX2; 1.
DR SMART; SM01188; ELK; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM01255; KNOX1; 1.
DR SMART; SM01256; KNOX2; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51213; ELK; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..355
FT /note="Homeobox protein knotted-1-like LET6"
FT /id="PRO_0000048973"
FT DOMAIN 237..257
FT /note="ELK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00559"
FT DNA_BIND 258..321
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 75..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 355 AA; 39796 MW; 9E9A1AFD75808C49 CRC64;
MEGGSSGNTS TSCLMMMGYG DHENNNNNNG NGNGNGNGNV TICAPPMMMM MPPPPPSLTN
NNNAETSNNN ILFLPFMDNN NNNNPQEDNN SSSSSIKSKI MAHPHYHRLL TAYLNCQKIG
APPEVVARLE EICATSATMG RSSSSSGGGI IGEDPALDQF MEAYCEMLTK YEQELSKPFK
EAMVFLSRIE CQFKALTLAP NSSHESALGE AMDRNGSSDE EVDVNNSFID PQAEDRELKG
QLLRKYSGYL GSLKQEFMKK RKKGKLPKEA RQQLVDWWLR HIKWPYPSES QKLALAESTG
LDQKQINNWF INQRKRHWKP SEDMQFVVMD AAHPHYYMDN VLANHFPMDM TPSLL
//
