ID LGC4_CAEEL Reviewed; 635 AA.
AC P54245;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 3.
DT 27-MAR-2024, entry version 160.
DE RecName: Full=Ligand-gated ion channel 4;
DE Flags: Precursor;
GN Name=lgc-4; ORFNames=F18G5.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP IDENTIFICATION.
RX PubMed=17503100; DOI=10.1007/s10158-007-0049-z;
RA Jones A.K., Davis P., Hodgkin J., Sattelle D.B.;
RT "The nicotinic acetylcholine receptor gene family of the nematode
RT Caenorhabditis elegans: an update on nomenclature.";
RL Invertebr. Neurosci. 7:129-131(2007).
CC -!- FUNCTION: Possible acetylcholine receptor.
CC -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO080202; CCD61933.1; -; Genomic_DNA.
DR PIR; A89606; A89606.
DR RefSeq; NP_509556.4; NM_077155.4.
DR AlphaFoldDB; P54245; -.
DR SMR; P54245; -.
DR BioGRID; 46072; 2.
DR STRING; 6239.F18G5.4.1; -.
DR GlyCosmos; P54245; 6 sites, No reported glycans.
DR PaxDb; 6239-F18G5-4; -.
DR EnsemblMetazoa; F18G5.4.1; F18G5.4.1; WBGene00017580.
DR GeneID; 181155; -.
DR KEGG; cel:CELE_F18G5.4; -.
DR AGR; WB:WBGene00017580; -.
DR WormBase; F18G5.4; CE45725; WBGene00017580; lgc-4.
DR eggNOG; KOG3645; Eukaryota.
DR HOGENOM; CLU_018074_0_3_1; -.
DR InParanoid; P54245; -.
DR OMA; WSHDITE; -.
DR OrthoDB; 2874383at2759; -.
DR PhylomeDB; P54245; -.
DR Reactome; R-CEL-112314; Neurotransmitter receptors and postsynaptic signal transmission.
DR Reactome; R-CEL-629594; Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
DR PRO; PR:P54245; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00017580; Expressed in larva and 3 other cell types or tissues.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0022848; F:acetylcholine-gated monoatomic cation-selective channel activity; IEA:InterPro.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated monoatomic ion channel activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904315; F:transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR CDD; cd18997; LGIC_ECD_nAChR; 1.
DR CDD; cd19051; LGIC_TM_cation; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt.
DR NCBIfam; TIGR00860; LIC; 1.
DR PANTHER; PTHR18945:SF828; LIGAND-GATED ION CHANNEL 4; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00254; NICOTINICR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor;
KW Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix;
KW Transport.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..635
FT /note="Ligand-gated ion channel 4"
FT /id="PRO_0000000405"
FT TOPO_DOM 25..324
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 402..599
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 600..620
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 177
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 225
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 282
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 625
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 238..252
FT /evidence="ECO:0000250"
SQ SEQUENCE 635 AA; 72916 MW; 7A3623E4E80B1948 CRC64;
MIICYSCLTV SILLTIKFVP CRFAGIEHQN TKSRVHFSLL DSRQENDTNH FEIAEAKFQK
PHNEENTIGT ITKFAPSVQE QHSSAVIPMP HFDQNRLEQA LRIKGSIDGT EEALYRSLLD
HTVYEKDVRP CIHHSQPTNV TFGFLLNQIV EMDERNQALT TRSWLNINWM DPRLSWNESL
WSEIKAIYIP HARIWKPDII LVNNAIREYY ASLVSTDVMV TSDGNVTWLF SALFRSSCPI
RVRYYPFDDQ QCDLKFASWS HDITEINLGL NTDKGDLSSY MNNSEFDLVD MTAVREVVTF
PSDTNSDWPI IVIRIHMHRR PLFYVFNHIV PCVLISSMAV LGFLMPPETG EKINMIITTL
LSMGVYLQSI TESIPPTSEG VPLIGMYYVS SLLMVCLATC VNVITLNMHR NGAANQGRHV
PAWMQKWILG YLATFMRMSI REPDSIALLK ASQSKKSTIR RSSILRDLKR VKNMSNVRAK
SKEQNANREC ECMDPLVHIY AESIMSCLAA DTKPMNGSTI REDFASESTF LGRVVSDGIM
PRISASSNSV LTEFETRFRR ILKRVYRSLQ QHEIREEILD ERSRIQWQWQ QLASVVDRLL
LCLFCTATLF TIICLLIVPV AYRDNDSMLS FLNFF
//
